Vitamin D supplementation and incidence of infections
| Condition | Age/years old | Study | Results | Reference |
|---|---|---|---|---|
| Healthy community | Mean 59 | Supplementation 50 mg/day in winter | No decrease in the severity and duration of upper respiratory infection | [74] |
| Residents (skilled nursing/assisted living facilities) | 80 ± 10 | High dose of 4,000 IU/day or standard dose of 400–1,000 IU/day followed for 12 months | Upper acute respiratory infection (ARI), skin and soft tissue infections are lower in the high dose group. All-cause hospitalization and death similar in both groups | [75] |
| Bone fracture | Mean 77 | Supplementation of 800 IU vitamin D daily | Fewer infection events, and decreased use of antibiotics than the placebo group but the results were not statistically different | [77] |
| Patients: antibody deficiency/increased susceptibility to infections | 18–75 | 12 months supplementation (4,000 IU/day oral) | Decrease in respiratory tract infections and prolonged time to the first respiratory tract infections (RTI) x placebo | [79] |
| Sepsis/septic shock patients | 55–70 | Supplementation 200,000 IU or 400,000 IU vitamin D single bolus | Higher levels of LL-37 and IFN-γ, reduced hospital length stay, and 30-day readmission | [80] |
VB: Writing—original draft, Writing—review & editing.
The author declares that there are no conflicts of interest.
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The study was supported by CAPES PrInt UNIFESP [88881.310735/2018-01]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
© The Author(s) 2023.