The clinical and laboratory characteristics of patients included in the study
Parameter
Patients with PAPS, n = 52
Average age, median [25; 75 percentiles], years
38.5 [31.5; 43.5]
Duration of the disease, median [25; 75 percentiles], years
9.0 [3.1; 13.0]
History of thrombosis, n (%)
Arterial
19 (37)
Venous
23 (44)
Arterial + venous
10 (19)
Recurrent thrombosis, n (%)
34 (65)
Obstetric pathology*, n (%)/n
18 (95)/19
IgG аCL, n (%)
by ELISA
40 (77)
by CLA
44 (85)
IgM аCL, n (%)
by ELISA
11 (21)
by CLA
19 (36)
IgG anti-β2-GPI, n (%)
by ELISA
38 (73)
by CLA
41 (80)/51
IgМ anti-β2-GPI, n (%)
by ELISA
12 (23)
by CLA
19 (36)
LA**, n (%)/n
6 (75)/8
IgA aCL by CLA, n (%)/N
26 (53)/49
IgA anti-β2-GPI by CLA, n (%)/N
26 (53)/49
IgG anti-β2-GPIDI by CLA, n (%)/N
37 (77)/48
AH, n (%)
22 (42)
Hypercholesterolemia, n (%)/n
1 (2)/46
Active smoking, n (%)
5 (10)
Type 2 diabetes mellitus, n (%)
1 (2)
Obesity, n (%)
15 (29)
Peri-operative, n (%)
0 (0)
Hormonal contraception, n (%)
0 (0)
Factor G20210A prothrombin (FII) mutation, n (%)/n
2 (6)/32
Factor V Leiden (FVL), n (%)
0 (0)/32
Therapy***, n (%)
DOACs
28 (54)
Warfarin
12 (23)
LMWH
4 (8)
Without anticoagulant therapy
8 (15)****
Low dose aspirin
18 (35)*****
Hydroxychloroquine
34 (65)
*: obstetric pathology was calculated in women who had pregnancy in their disease course, in the numerator—“n” and “%” of women with obstetric pathology, in the denominator—“n” of women who had pregnancy in their disease course; numerator is the “n” and “%” of patients with positive aPLs, and denominator is the “n” of patients who had aPLs determination; **: LA study was performed in patients who have not taken anticoagulant therapy; ***: therapy at the time of inclusion in the study; ****: patients were diagnosed with APS for the first time, so they did not receive anticoagulant therapy before being included in the study; *****: five patients received aspirin in combination with anticoagulants, 13 patients received aspirin without anticoagulants. AH: arterial hypertension; CLA: chemiluminescent assay; DOACs: direct oral anticoagulants; ELISA: enzyme-linked immunoassay; LMWH: low-molecular-weight heparin; median [25; 75 percentiles]: median with interquartile range; n: number of patients
Declarations
Acknowledgments
The study conducted within the framework of fundamental research project FURS-2022-003 [1021051402790].
The authors declare that they have no conflicts of interest.
Ethical approval
The study was conducted in accordance with the Declaration of Helsinki, and approved by Ethics Committee of V.A. Nasonova Research Institute of Rheumatology (Protocol No. 25 dated December 19, 2019).
Consent to participate
Informed consent to participate in the study was obtained from all participants.
Consent to publication
Informed consent to publication was obtained from relevant participants.
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