Table Info

Table 2.

Laboratory and clinical parameters of patients positive or negative for anti-FH autoantibodies at disease onset

Parameters	Anti-FH positive, n = 12	Anti-FH negative, n = 36	P-value
Age (years old)	8 ± 3 (6–11)	7 ± 6 (1–12)	0.60^†
Sex—male	8 (67%)	16 (44%)	0.32^†
Anti-FH antibodies (AU/mL)	2,165 ± 2,391 (400–3,250)	4 ± 8 (0–4)	< 0.0001^†
Hemoglobin (g/dL)	7.7 ± 2.3 (5.6–10.0)	7.6 ± 2.4 (6.5–9.1)	0.96^†
Hematocrit (%)	23 ± 7 (17–31)	22 ± 7 (18–27)	0.89^†
Platelets (× 10⁹/L)	48 ± 26 (24–62)	58 ± 39 (28–67)	0.44^†
LDH (IU/L)	3,669 ± 1,839 (2,355–4,760)	3,363 ± 2, 489 (1,530–4,515)	0.70^†
Urea (mg/dL)	148 ± 47 (121–171)	136 ± 69 (78–189)	0.49^†
Creatinine (mg/dL)	2.50 ± 1.27 (1.53–3.80)	4.56 ± 3.86 (1.37–7.47)	0.10^†
Prodromes
Gastrointestinal manifestations
Vomiting	6 (50%)	11 (31%)	0.30^¥
Diarrhea	0 (0%)	18 (50%)	< 0.01^¥
Not specified	-	3 (8%)	-
Fever	3 (25%)	4 (11%)	0.34^¥
Petechial rash	2 (17%)	3 (8%)	0.59^¥
Infection
Upper respiratory tract	2 (17%)	2 (6%)	0.26^¥
STEC	1 (8%)	-	-
Extrarenal manifestations
Neurological (severe headache, seizures, sensory alterations)	4 (33%)	13 (36%)	1.00^¥
Hypertension	5 (42%)	10 (28%)	0.48^¥

Values represent mean ± standard deviation and 25th–75th percentile or percentage of the total depending of the analyzed parameter. The data in the last column are the P-values of ^† t-test or ^¥ Fisher’exact test

Declarations

Acknowledgments

We would like to thank the patients and their families for their participation in the study, as well as the physicians and the institutions for their contribution to the acquisition of patients data. We thank James Castaneda, Bespoke English, for his diligent proofreading of this manuscript.

Author contributions

CDS: Conceptualization, Investigation, Visualization, Writing—original draft, Writing—review & editing. JT and SC: Investigation, Formal analysis. LA and PAC: Investigation, Resources, Writing—review & editing. FJM: Investigation, Resources. MFA: Investigation, Formal analysis, Writing—review & editing. ASL: Conceptualization, Investigation, Visualization, Resources, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The study was approved by the Institutional Review Board (or Ethics Committee) of Academia Nacional de Medicina, Buenos Aires (28/22/CEIANM, dated 7/09/2022), and it complies with the Declaration of Helsinki.

Consent to participate

Informed consent to participate in the study was obtained from parents/legal guardians.

Consent to publication

Not applicable.

Availability of data and materials

The datasets for this manuscript are not publicly available due to privacy and ethical concerns. Requests for accessing the datasets should be directed to Célia Dos Santos (cdossantosimex@gmail.com).

Funding

This study was supported by Fundación Baron, CONICET, Agencia I+D+I – FONCYT and Academia Nacional de Medicina de Buenos Aires providing fellowship funding for graduate/PhD students and funding for material and reagents. This study was partially funded by educational grants (2015–2017) from Alexion Argentina and grant for clinical support from Laboratorios Raffo (2018–2022). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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