Table Info

Table 1.

Comparisons of the different studies analysing the signification of aPZ-Ab in women with obstetrical complications

References	Controls (n)	Cut-off (AU/mL)	Patients	Conclusions
[13]	191 healthy mothers, matched for age, number of pregnancies, and time elapsed since the end of the last pregnancy	IgG: 75th pctl: 7.1 98th pctl: 14 IgM: 75th pctl: 5.3 98th pctl: 11.9	112 women with unexplained primary recurrent embryo losses before the 8th week of gestation 41 women with 1 unexplained episode of foetal death from the 10th week 18 patients with 1 episode of severe pre-eclampsia	IgG levels higher in women with recurrent embryo losses and in women with foetal death. IgM levels higher in women with recurrent embryo losses, foetal death, and severe pre-eclampsia.
[15]	283 age-matched multiparous non-pregnant women	IgG: 75th pctl: 9.2 95th pctl: 12.5 99th pctl: 15 IgM: 75th pctl: 4.7 95th pctl: 8.8 99th pctl: 12.3	265 women with medically confirmed diagnosis of recurrent spontaneous miscarriage (RSM)	Increase in RSM risk with increasing levels of anti-PZ IgM and IgG titers and increased prevalence of elevated anti-PZ (IgG and IgM) > 99th pctl.
[16]	45 non-pregnant women 70 women with a normal pregnancy	IgG: 75th pctl: 5.3 90th pctl: 7.3 95th pctl: 18.2 IgM: 75th pctl: 21.1 90th pctl: 26.9 95th pctl: 36	123 women with pre-eclampsia 51 women with a neonate with small birthweight (SBW) 51 women with foetal death	Non-pregnant women had higher median aPZ-Ab (IgG and IgM) levels than women with a normal pregnancy. aPZ-Ab (IgG) are higher in women with a neonate with SBW than in pregnant controls. aPZ-Ab (IgG) are higher in women with a neonate with SBW than in women with pre-eclampsia or foetal death. aPZ-Ab (IgM) are more often > the 90th pctl in women with SBW and in women with pre-eclampsia when the placenta had villous infarcts or persistent muscularization of basal plate arteries. aPZ-Ab (IgM) > the 75th pctl in case of inflammation of the umbilical vessels in women with foetal death.
[17]	71 normal pregnant women	IgG: 50th pctl: 2.9 IgM: 50th pctl: 12.3	67 women in spontaneous labour at term 138 women with an episode of spontaneous preterm labour (49 with term delivery; 35 with preterm delivery and intra-amniotic infection; 54 with preterm delivery without intra-amniotic infection)	No differences between pathological pregnancies and the controls.

Declarations

Acknowledgments

The authors thank Polly Gobin for her editorial assistance and Dr. Jean Amiral for helpful discussion.

Author contributions

TP and SZC: Resources, Visualization, Writing—review & editing. THA: Resources, Writing—review & editing. MV: Conceptualization, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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