Table Info

Table 4.

Main laboratory exploration methods for autoantibodies associated with hemostasis disorders

Laboratory testing	Assay principle	Measurement type
Functional assays	Inhibition of activity	Measurement of factor activity; mixing studies.
Titration of inhibitor titer (Bethesda method)	Incubation of a normal sample with serial dilutions of patient sample and testing residual activity	Dilution inhibiting 50% of activity (corresponds to 1 unit)
Flow cytometry	Detection of circulating autoantibodies through their binding to Plt or blood cell GPs	Detection of bound antibodies to specific GPs
ELISA	Autoantigen capture-based assays	Detection of autoantibody by ELISA
MAIPA	Immunocapture of Plt GP and reactive autoantibodies	Identification of specific anti-GP autoantibodies
Coombs test	Detection of cell-bound antibodies	Detection of global anti-cell autoantibodies

Declarations

Author contributions

JA: Conceptualization, Writing—original draft, Writing—review & editing.

Conflicts of interest

JA is consultant for HYPHEN BioMed SAS.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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