Table Info

Table 1.

TNF-α and IL-6 secretion in LPS-stimulated CD11c⁺ cells treated with NOB, HMF, or GEN

Group	TNF-α (ng/mL)	IL-6 (pg/mL)
Control	234 ± 4^*	471 ± 5
NOB	250 ± 20	390 ± 28^#
HMF	198 ± 13	431 ± 40
GEN	327 ± 18^**	432 ± 39

^* Mean ± SD; ^** significantly increased compared to control (P < 0.01); ^# significantly decreased compared to control (P < 0.05). IL-6: interleukin-6; TNF-α: tumor necrosis factor-α; NOB: nobiletin; HMF: heptamethoxyflavone; GEN: genistein; LPS: lipopolysaccharide

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/1003144_sup_1.fcs.

Declarations

Acknowledgments

We thank Ushio-Chemix Co. providing nobiletin, heptamethoxyflavone, and natsudaidain and Ikeda-Yakusou Co. for providing sudachitin.

Author contributions

YT: Investigation, Visualization, Writing—original draft. HO: Investigation, Methodology. AN: Writing—original draft, Writing—review & editing. MN: Formal analysis, Writing—original draft. TS: Funding acquisition, Investigation, Supervision, Writing—original draft. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All studies were performed in accordance with the ethical guidelines for animal experimentation by the Institute of Biomedical Sciences, Tokushima University, Japan, and were approved by the institution review board of the animal ethics committee (T2020-107). All studies were also performed in accordance with the Declaration of Helsinki.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.

Funding

This study was supported, in part, by JPSS KAKENHI [JP19K1176800, JP22K11701]; by Kieikai Research Foundation; by Fuji Foundation for Protein Research; and by Tojuro Iijima Foundation for Food Science and Technology. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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