Model parameters, descriptions, and values are chosen for simulations
Notation
Value
Description
C
7 × 10–1
Cancer cells
I
2.1 × 10–2
Immune system
E
3.8 × 10–1
Elimination of cancer cells
IC
5.7 × 10–2
Complex formed between the immune system and cancer cells
c
1 × 10–7
Concentration of chemokines
n
3.42 × 10–10
Concentration of immune cells
k
1.8 × 10–8
Degradation rate of chemokines
Dn
1.3 × 10–4
Diffusion coefficient of immune cells
t
Est
Time
χ
Est
Sensitivity of immune cells to chemokines
D
4.13 × 10–2
Diffusion coefficient of chemokines
cn
5 × 10–3
Sensitivity of concentration of chemokines
Note. Adapted from “Modeling cancer immunoediting in tumor microenvironment with system characterizationthrough the ising-model Hamiltonian” by Rojas-Domínguez A, Arroyo-Duarte R, Rincón-Vieyra F, Alvarado-Mentado M. BMC Bioinformatics. 2022;30:200. (https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-022-04731-w#citeas). CC BY.
Declarations
Acknowledgments
This work is supported under a research project entitled “Mathematical modeling of tumor growth and its treatments” granted by the U.P. State Government under the supervision of Prof. Sanjeev Kumar.
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