Table Info

Table 1.

Demographic and clinical characteristics of NSCLC patients

Demographic and clinical data	Number and percentage (%)
Total of patients	18 (100%)
Sex
Male	12 (66.7%)
Female	6 (33.3%)
Histologic subtype
Adenocarcinoma	11 (61.1%)
Squamous cell carcinoma	4 (22.2%)
NSCLC	3 (16.7%)
ECOG status
ECOG status 0	5 (27.8%)
ECOG status 1	11 (61.1%)
ECOG status 2	2 (11.1%)
Response to first-line treatment
Complete response	2 (11.1%)
Partial response	4 (22.2%)
Stable disease	11 (61.1%)
Progressive disease	1 (5.6%)

The proportion of patients in each category indicated was calculated from the total absolute number of patients in this study. ECOG: Eastern Cooperative Oncology Group; NSCLC: non-small cell lung cancer

Note. Adapted from “Thymic Polypeptide Fraction Biomodulina T Decreases Exhausted and Terminally Differentiated EMRA T Cells in Advanced Lung Cancer Patients Treated With Platinum-Based Chemotherapy” by Suárez GM, Catalá M, Peña Y, Portela S, Añé-Kourí AL, González A, et al. Front Oncol. 2022;12:823287 (https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.823287/full). CC BY.

Declarations

Acknowledgments

The authors are extremely thankful to patients and their relatives who so valuably supported this research. The authors are also grateful for the participation of physicians, nurses, and colleagues at the Medical & Surgical Research Center. Thanks to Dr. Mays Abuhantash, Aya Zeid Zakaria, and Dr. Syed Mazher Hussain for their contributions in reviewing this manuscript and providing their valuable comments. The authors also thank the Center for Molecular Immunology for supporting the completion of this study.

Author contributions

GMS: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. MC, YP, and SP: Methodology, Project administration. ALA-K and AL: Conceptualization, Writing—review & editing, Supervision. AG: Resources. PL-L: Software. MD and MM: Methodology, Project administration. KP: Resources, Investigation. JH: Investigation. MCR: Conceptualization, Writing—review & editing. NL, ZM, and TC: Supervision, Writing—review & editing. AB-H: Writing—review & editing. DS: Conceptualization, Writing—original draft, Writing—review & editing, Methodology, Project administration, Resources, Investigation, Software, Supervision, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The author declares that there are no conflicts of interest.

Ethical approval

The Biomodulina T- CIMAvax-EGF-Advanced Non-Small Cell Lung Cancer-Adults was approved by the Institutional Review Boards of the participating hospitals and by the National Regulatory Authority in Cuba. The research protocol is registered in https://rpcec.sld.cu/en/trials/RPCEC00000358-En, the Cuban Public Registry of Clinical Trial (Spanish acronym: RPCEC). The study was done in compliance with the principles of Good Clinical Practices (according to the International Conference of Harmonization) and the Declaration of Helsinki (2013).

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher. The research protocol is available at https://rpcec.sld.cu/en/trials/RPCEC00000358-En, the Cuban Public Registry of Clinical Trial (Spanish acronym: RPCEC).

Funding

Not applicable.

Copyright

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