Table Info

Table 3.

Applications of artificial factors for disease therapy

Artificial factors	Characteristics	Disease	Clinical stage	Reference(s)
IFN-α mutant	Mutation	Cancer	Preclinical	[108]
Myeloid-biased, IL-10 variants	Mutation	Autoimmune diseases	Preclinical	[109]
PEG-IL-2, NKTR-214	PEG modification	Solid tumors	Phase I/II	NCT02869295, NCT02983045
IL-2-mutein-Fc, AMG592	Mutation and fusion with Fc protein	Autoimmune diseases	Phase I	NCT03451422, NCT03410056 NCT03422627
IC7FC	Chimeric cytokines fused with the antibody	Type 2 diabetes	Phase I	[61]
PCCPs	The pH-response properties were grafted onto the polypeptides	Cancer	Preclinical	[83]
HGF mimics	DNA aptamer	Fulminant hepatitis	Preclinical	[83]
IR-a62	DNA aptamer modulator	diabetes	Preclinical	[107]

IFN: interferon; IR: insulin receptor; HGF: hepatocyte growth factor; PCCPs: pH-controllable cell-penetrating polypeptides

Declarations

Acknowledgments

We would like to acknowledge the funding support from Joint Institute of Tobacco and Health, the National Natural Science Foundation of China, the Scientific Research Program of FuRong Laboratory, and the Natural Science Foundation of Hunan Province.

Author contributions

XZ: Conceptualization, Writing—original draft. HHW: Conceptualization, Writing—review & editing. TW, XF, TZ, RQ, and YW: Writing—original draft. MW, YZ, ML, NC, and YG: Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

The study was supported by the Joint Institute of Tobacco and Health [2022539200340039]; the National Natural Science Foundation of China [22177030]; the Scientific Research Program of FuRong Laboratory [2023SK2104]; and the Natural Science Foundation of Hunan Province, China [2023JJ40814]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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