Role of NEAT1 in different autoimmune diseases

Disease typeEffects of NEAT1Reference
Systemic lupus erythematosusUpregulation of the activation of MAPK signaling pathway in TLR4-mediated inflammatory process;Zhang et al. [20]
Upregulation of chemokines and cytokines;Xiang et al. [21]
Abnormal activation of IFN-I signaling.Dong et al. [23]
Rheumatoid arthritis (RA)Regulating glutamine metabolism and FLSs-RA dysfunction in FLSs of RA;Wang et al. [26]
Influencing FLSs physiological function by inhibiting miR-23a expression;Wade et al. [27] and
Zhao et al. [28]
Regulating the NF-κB signaling pathway;Kawahara et al. [30]
Influence of CD4+ T cells differentiation into Th17 cells;Liu et al. [32] and Shui et al. [33]
RA aggravation via p300/CBP/IL-18 axis.Guo et al. [6]
PsoriasisUpregulation of inflammatory factors;Jin et al. [35]
Controlling the proliferation and differentiation of epidermal cells by interacting with miRNA.Wang et al. [36] and Tang et al. [37]
Multiple sclerosisRegulating the imbalance of Th1/Th2;Karimi et al. [40]
Upregulation of TNF-α and IL-17.Li et al. [41]

NEAT1: nuclear paraspeckle assembly transcript 1; MAPK: mitogen-activated protein kinases; FLSs: fibroblast-like synoviocytes; NF-κB: nuclear factor κB