Table Info

Table 1.

Multiple scoring systems have been developed to assess biochemical response to UDCA treatment [92]

Scoring System	Criteria for treatment of non-responsiveness	Time of evaluation from treatment initiation
Barcelona	ALP decrease ≤ 40% of the initial level and ALP ≥ ULN	12 months
Paris II	ALP ≥ 1.5 × ULN or total bilirubin > 1 mg/dL or AST ≥ 1.5 × ULN	12 months
Rotterdam	Total bilirubin ≥ ULN, albumin < LLN, or both	12 months
Toronto	ALP ≥ 1.67 × ULN	24 months
UK-PBC formula	Uses baseline albumin and platelet count, along with 12-month measurements of total bilirubin, ALP, and AST or ALT	12 months
GLOBE formula	Uses age, total bilirubin, ALP, albumin, and platelet count	12 months

Declarations

Author contributions

MBAE, IE, and AAAA: Investigation, Writing—original draft. JLB: Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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