Table Info

Table 2.

Differences in the ratio of TRP-KYN pathway metabolites between HCs and PSOs

Ratios of metabolites	HCs (mean ± SD)	PSOs (mean ± SD)
KYN/TRP	0.0382 ± 0.0102	0.0369 ± 0.0121
KYNA/KYN	0.0196 ± 0.0060	0.0188 ± 0.0085
AA/KYN	0.0087 ± 0.0027	0.0092 ± 0.0048
3HK/KYN	0.0093 ± 0.0039	0.0111 ± 0.0052	*
3HAA/3HK	0.4319 ± 0.2317	0.9026 ± 0.4619	***
3HAA/AA	0.499 ± 0.385	1.0893 ± 0.614	***

P < 0.05; ^***P < 0.001 vs. HCs

Declarations

Acknowledgments

The authors would like to thank Mrs. Kayoko Tanaka for assisting data collection.

Author contributions

Seishima M and KS contributed conception and design of the study; RS and YY performed the experiments; KF and YM organized the database; Sakurai M and YY performed the statistical analysis; Seishima M wrote the first draft of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

The authors declare that there are no conflicts of interest.

Ethical approval

The study protocol was approved by the ethics committee of Gifu University Graduate School of Medicine (2018–1949).

Consent to participate

The informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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