Table Info

Table 4.

Subgroup analysis of ΔSOFAday07 after PSM

	Tα1 (n = 111)		Placebo (n = 111)		P value
	n	Median, IQR	n	Median, IQR	P value
Age
Non-elderly	37	40 (22, 72)	39	22 (–8, 61)	0.062
Elderly	74	47 (17, 67)	72	35 (1, 57)	0.066
Sex
Male	84	43 (16, 66)	87	33 (–2, 58)	0.056
Female	27	54 (29, 75)	24	31 (–8, 66)	0.117
Initial mHLA-DR
Immunoparalysis	26	47 (13, 73)	29	31 (–1, 60)	0.116
No immunoparalysis	85	45 (21, 67)	82	33 (–6, 60)	0.047
Lymphocyte day 0
< 0.7 × 10⁹/L	38	56 (30, 78)	39	44 (3, 62)	0.102
0.7–1.1 × 10⁹/L	33	44 (16, 62)	31	27 (–1, 59)	0.225
> 1.1 × 10⁹/L	39	39 (15, 67)	41	26 (–12, 59)	0.093
Pre-existing conditions
No	18	55 (36, 71)	21	0 (–19, 51)	0.006
Yes	93	42 (18, 68)	90	38 (7, 61)	0.207
Initial SOFA score
≤ 8	70	43 (18, 70)	73	30 (–11, 60)	0.033
> 8	41	45 (26, 67)	38	35 (17, 60)	0.198
APACHE II score
≤ 21	55	48 (19, 76)	61	32 (–10, 60)	0.048
> 21	56	43 (20, 62)	50	33 (4, 57)	0.124
Intervention time
Early	41	58 (32, 78)	48	39 (15, 62)	0.041
Delayed	70	36 (16, 63)	63	27 (–16, 56)	0.055

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/100345_sup_1.pdf.

Declarations

Acknowledgments

We would like to thank all of the doctors, nurses, technicians, and patients involved at the six participating hospitals for their dedication to the ETASS trial.

Author contributions

FP, YL and JW drafted the manuscript. FP, LZ and LW carried out the data analysis. BG, LL, MC, YN and LW collected and discussed the data. JW, FP and XG designed all research, interpreted data and edited the manuscript. All authors approved the final manuscript as submitted and agreed to be accountable for all aspects of the work.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The ETASS trial was approved by the ethics committee of the First Affiliated Hospital of Sun Yat-sen University (200815). Written informed consents were obtained from the patients or next of kin.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

Requests for accessing the datasets should be directed to contact the corresponding author Prof. Jianfeng Wu. The supplementary tables can be found in the Supplemental materials section.

Funding

This work was funded by Guangdong Clinical Research Center for Critical Care Medicine (2020B1111170005), by Sun Yat-sen University Clinical Research Program 5010 (2007015, 2019002), and by Program for the Natural Science Foundation of Guangdong Province (2016A030313269). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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