T cell subsets

T cell subsetsSurface markersCytokine productionGene expression of critical transcription factors
Th1/Tc1CXCR3IFN-γTBX21
Th2/Tc2CCR4IL-4, IL-13, IL-5GATA3
Th17/Tc17CCR4, CCR6IL-17A, IL-17F, IL-22RORC
Th17 + 1/Tc17 + 1CXCR3, CCR6IL-17A, IL-17F, IFN-γRORC, TBX21
Th22/Tc22CCR4, CCR6, CCR10IL-22, TNF-αAHR
Tfh/TfcCXCR5IL-21BCL6
CD4+Treg/CD8+TregCCR2, CCR4IL-10, TGF-βFOXP3

Tfh: T follicular helper; Tfc: T follicular cytotoxic; Treg: regulatory T; TGF: transforming growth factor