Table Info

Table 4.

Self-replicating RNA viruses and examples of clinical trials on cancers

Vaccine candidate	Cancer	Status	Reference
VEE-HER2 ECD-TM (VRP-HER2)	Breast	Phase I: 1 PR, 2 SD, good tolerance	[155]
VEE-HER2 ECD-TM (VRP-HER2)	Breast	Phase II: study in progress	[155]
SFVEnh-HPV E6/E7 (Vvax001)	Cervical	Phase I: immunogenicity of all 12 patients	[156]
VEE-CEA	Colon	Phase I: prolonged survival	[157]
VEE-CEA	Colon	Phase II: study in progress	[158]
MV-CEA	Ovarian	Phase I: dose-dependent, SD in 14/21 patients	[159]
VEE-CEA	Pancreatic	Phase I: prolonged overall survival	[159]
VEE-PSMA	Prostate	Phase I: safe, but weak immunogenicity	[160]

PR: partial response; SD: stable disease; SFVEnh: SFV vector with translation enhancement signal from C protein; TM: transmembrane; VRP: virus replicon particle

Declarations

Author contributions

The author contributed solely to the work.

Conflicts of interest

The author declares that he has no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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