Table Info

Table 2.

γδ T cells in obese humans

Subjects studied	IL-17 production by γδ T cells	IFNγ production by γδ T cells	Number and function of γδ T cells	Reference
Obese adults		PB decrease	Decrease of γδ cells in the PB, which are less capable of IFNγ production and express less of IL-2R and IL-7R	[58]
Obese women		PB decrease	Decrease, less IL-2 and IFNγ production	[59]
Obese adults			Decrease Vγ9δ2/γδ ratio in PB	[61]
Morbid Obesity adults			PB IFNγ⁺ γδ T cells are not correlated with obesity	[63]
Obese children			Increase of Vγ9δ2 cells in PB	[64]
Obese adults with OSA			Decrease of γδ T cells in PB	[60]
Adults with esophageal cancer	Increase in omental fat	Increase in omental fat	Increase relative to PB of Vδ1 and Vδ3⁺ cells in omental fat, producing IL-17	[65]
Lean adults			Equally represented in VAT and PB	[61]
AT of 120 obese and 275 controls			Decreased γδ T cells in the AT of obese people, leading to decrease sympathetic activity	[66]
In vitro study of effects of adipocyte conditioned medium on immune functions			Adipocyte conditioned medium decreases responses of DC to γδ T cell activation signals, with decreased IL-1/IL-10 ratio	[67]

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