Research of γδ T cells with antibody adjuvant
Name | Target | Tumor type | Reference |
---|---|---|---|
mAb | |||
hu14.18 | GD2 | Neuroblastoma/Ewing’s sarcoma | [57–59] |
Rituximab & GA101 | CD20 | B cell lymphoma/CLL | [54–56] |
Trastuzumab | HER2 | Breast cancer | [54, 55] |
Alemtuzumab | CD52 | Lymphoma | [55] |
BiTE | |||
Her2-CD3 & (Her2)2 × Vγ9 | HER2 & CD3/Vγ9 | PDAC | [61, 62] |
Vγ9/CD123 bispecific antibody | CD123 & Vγ9 | AML | [64] |
Y111 | PD-L1 & CD3 | NSCLC | [60] |
Bispecific nanobody | |||
7D12-5GS-6H4 | EGFR & Vδ2 | Colon adenocarcinoma | [65] |
anti-CD1d-Vδ2 | CD1d & Vδ2 | CLL | [68] |
JZ and XJ wrote the initial draft of the manuscript; JZ prepared the figure; HZ and WW organized literature for manuscript; XW and ZJ revised the final draft. All authors read and approved the submitted version.
The authors declare that they have no conflicts of interest.
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This study was supported in part by grants from the National Natural Science Foundation of China (Nos. 81800143, 81770150, 81200388, and 82170220), Natural Science Foundation of Guangdong Province (No. 2020A1515010817 and 2022A1515010313), the Science and Technology Program of Guangzhou City (No. 202201010164), National Innovation and Entrepreneurship Training Program for Undergraduate (No. 202010559081), Guangdong’s Innovation and Entrepreneurship Training Program for Undergraduate (Nos. 202010559081 and 202210559083), “Challenge Cup” National Undergraduate curricular academic science and technology works by race (No. 21112027) and Guangdong College Students’ Scientific and Technological Innovation (Nos. CX22438, CX22446, and CX21285). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
© The Author(s) 2022.