NK cell ontogeny and related markers

NK cell typeMarkersTranscription factor for progressionNext stage in the progressionSource
CLPIL-7Rα, CD127, Lin–NFIL3, GATA3, Id2Pro-B, Pre-T, ILCs, CD122+ early NKP lineageAbel et al. [21]
PreNKPCD56–/16–,57–/T-bet–/Eomes–/ID2+-NKPAbel et al. [21]
NKPCD56–/16–,57–/T-bet–/Eomes–/CD122IL-15RαiNKSojka et al. [16]
iNKCD56–/16–,57–/T-bet–/Eomes–/NK1.1/NKG2DNFIL3cNKSojka et al. [16]
iNKCD56–/16–,57–/T-bet–/Eomes–NFIL3uNKSojka et al. [16]
iNKCD56–/16–,57–/T-bet–/Eomes–T-bettrNK liverSimonetta et al. [22]
iNKCD56–/16–,57–/T-bet–/Eomes–GATA3, IL-15Thymic NKSojka et al. [16]
uNKCD56bright/16–, 57–/49a+/T-bet+/Eomes++--Simonetta et al. [22]
Thymic NKCD127+--Sojka et al. [16]
trNK liverCD56bright/16–,57–/49a+/T-bet+/EOMES–/DX5–--Sojka et al. [16], Simonetta et al. [22]
cNKCD56bright/16–,57–/T-bet++/EOMES+++/CD49a–/DX5+IL-12, IL-15, IL-18Stage 5 cNKSojka et al. [16], Simonetta et al. [22]
Stage 5 cNKCD56dim/16+,57–/T-bet++/EOMES++-Adaptive NKAbel et al. [21]
Adaptive NKCD56dim/16+,57+/T-bet+++/EOMES+--Abel et al. [21]

NKG2D: NK group 2, member D; Lin: Lineage; -: none