Table Info

Table 2.

Gene set enrichment analysis of HGAL interacting proteins

Gene set	No. of genes in set	Overlap with HGAL interactome	–log₁₀ (FDR)
GO_CYTOSKELETON	1967	30	14.91
GO_CELL_JUNCTION	1151	22	12.19
GO_CELL_LEADING_EDGE	350	14	11.19
WANG_TUMOR_INVASIVENESS_UP	374	14	10.86
GO_CYTOSKELETAL_PART	1436	21	9.64
GO_CELL_PROJECTION	1786	22	8.85
GO_IMMUNE_SYSTEM_PROCESS	1984	22	8.10
GO_CYTOSKELETAL_PROTEIN_BINDING	819	15	7.79
GO_ACTIN_CYTOSKELETON	444	12	7.76
GO_ACTIN_BINDING	393	11	7.15
GO_CYTOSKELETON_ORGANIZATION	838	14	6.72
GO_LAMELLIPODIUM	172	8	6.52
GO_MICROTUBULE_CYTOSKELETON	1068	15	6.37

FDR: false discovery rate; GO: gene ontology

Note. Reprinted from “HGAL inhibits lymphoma dissemination by interacting with multiple cytoskeletal proteins,” by. Jiang XY, Lu XQ, Gentles AJ, Zhao DK, Wander SA, Zhang Y, et al. Blood Adv. 2021;5:5072–85 (https://doi.org/10.1182/bloodadvances.2021004304). CC BY NC ND.

Declarations

Acknowledgments

We thank to Sylvester Comprehensive Cancer Center for its continuous support over the years that included access to facilities and funding.

Author contributions

XJ and ISL: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing—original draft. ISL: Funding acquisition, Project administration, Resources, Supervision, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

ISL was approved by National Cancer Institute [1R01CA233945, U01CA195568], University of Miami SCCC (the Intramural Funding Program), Dwoskin and Anthony Rizzo Families Foundations and Jaime Erin Follicular Lymphoma Research Consortium. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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