Processes enriched in neurons submitted to overstimulation by glutamate for 60 min and pathways related to and affected by excitotoxicity
| Enriched process (glutamate overstimulation for 60 min) | Molecular mechanisms by affected by excitotoxicity |
|---|---|
| Protein localization at the membrane | Alterations in glutamate receptors (particularly NMDAR) and glutamate transporter functioning [9] |
| Organelle transportation along microtubule and regulation of cellular component movement | Changes in Ca2+ buffering and transposition of mitochondria [87] |
| Negative regulation of cellular amine metabolic | Over-recycling of glutamate in a dynamic pool, maintained through the glutamate-glutamine cycle by glutamine synthase in the cytoplasm of astrocytes and excitatory amino acid transporter dysfunction [88, 89] |
| Response processes to axon injury | Degeneration of axons and dendrites by a process associated with excessive increases in [Ca2+]i and mitochondrial dysfunction [90] |
