Genetic factors associated with MG
| The association | Study |
|---|---|
| CTLA-4 gene: rs733618*C allele frequency was higher in MG than controls, rs231775*A allele frequency was lower in OMG than controls and generalized MG, rs3087243*A allele frequency was lower in OMG than generalized MG. The combination of rs733618*C, rs231775*G, and rs3087243*G alleles was more frequent in MG and OMG than in other patients. | Cai et al. [63] |
| CTLA-4 methylation and CTLA-4 expression were higher in MG than in controls. | Fang et al. [64] |
| Overexpression of CXCR4 in poor prognosis TAMG. | Yang et al. [66] |
| DRB1 07 and 0403 alleles as risk factors in LOMG, DRB1*0301 and 1301 alleles as protective factors in LOMG. | Ling et al. [67] |
| Lower DQA1*0103 frequency in OMG than in the control group. Higher DQA1*0301 and lower DQB1*0601 frequency in MG patients with thyroid-associated ophthalmopathy. Higher DQB1*0501 frequency in the OMG and OMG+ thyroid-associated ophthalmopathy than in the control group. | Yang et al. [66] |
| RyR, CACNA1S, and SLAMF1 as MG biomarkers. | Na et al. [68] |
| CHRNA1, CHRNB1, chromosomes 2q31.1, 10p14, and 11q2, PTPN22, TNFRSF11A, and HLA-DQA1/HLA-B were associated with MG. | Chia et al. [69] |
| HLA-DRB1/HLA-B, TNFRSF11A, and AGRN were associated with MG. | Topaloudi et al. [70] |
