Table Info

Table 2.

Major findings supporting the involvement of CB₂R in depressive disorders

Animal studies
Genetic studies	Genetic manipulation	Animal specie	Experimental test	Behavioral changes		References
	CB₂xP	Mouse, ICR	TST	↓ immobility time		[39]
			NSFT	↓ latency time and ↑ food (g) consumption		[39]
			CMS	↑ resistance (↑ sucrose 1% consumption and ↓ immobility time in TST)		[39]
	CB₂^–/–	Mouse, ICR	TST	↑ immobility time		[44]
	DAT-Cnr2^–/–	Mouse, C57BL/6J	TST, FST	↑ immobility time		[69]
Pharmacological studies	Drug	Animal specie	Experimental test	Dosis	Behavioral changes	References
	AM630 (CB₂R antagonist)	Mouse, ICR	CMS	1 mg/kg per 12 h (4 weeks)	Antidepressive actions (↑ immobility time in TST and ↑ sucrose 1% consumption)	[39]
	AM630 (CB₂R antagonist)	Mouse, BALB/c C57BL/6J	CMS	3 mg/kg per 24 h (4 weeks)	No effect	[45]

Human studies
Variable	Population	Results	References
Q63R polymorphism	Japanese	↑ incidence	[45]
CB₂R expression	Caucasian	↓ in DLPFC and amygdala	[56]

TST: tail suspension test; NSFT: novelty suppressed feeding test; FST: forced swimming test; CMS: chronic mild stress

Declarations

Acknowledgments

We thank all participants in this study. We greatly appreciated Biorender for helping to create figure 1.

Author contributions

MSGG and JM conceived the presented idea. MSGG took the lead in writing the manuscript. FN and AG wrote the manuscript in consultation with MSGG. All authors provided critical feedback and helped shape the research, analysis, and manuscript.

Conflicts of interest

The authors declare no conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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