Table Info

Table 6.

Effects of antidepressants on the HPA axis

Drug group	Drug	Properties
Tricyclic antidepressants	Imipramine	Reduced HPA axis responsiveness over 6 weeks [179] No change in cortisol levels over 4 weeks [180]
	Nortriptyline	Reduced ACTH and no change in cortisol over 4 weeks [182]
	Amitriptyline	No effects on circadian variations in cortisol over 6 weeks [183]
SSRIs	Fluoxetine	Reduced ACTH and no change in cortisol over 4 weeks [180, 181]
	Citalopram	Transient increase in morning cortisol after 6 days [187] Reduced HPA axis responsiveness over 4 weeks [188]
	Escitalopram	Transient stimulation of cortisol response to dexamethasone at 1 week [184, 185] No effects on diurnal secretion of ACTH or cortisol over 8 weeks [186]
	Fluvoxamine	No effects on circadian variations in cortisol over 6 weeks [183]
SNRIs	Venlafaxine	No effects on cortisol over 4 weeks [190]
Other antidepressants	Mirtazapine	Transient increase in morning cortisol after 1 week [189]

Declarations

Author contributions

RPR: Conceptualization, Methodology, Writing—original draft, Writing—review & editing. The author has read and approved the submitted version.

Conflicts of interest

The author declares that he has no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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