Main characteristics of the included articles

Author
Year
ResultsIntervention
Protocol
Outcome measuredAge and genderParticipant countLocationStudy designQuality assurance**
Park et al. (2020)
[37]
Tryptophan, kynurenine, and serotonin may be useful as metabolic biomarkers for improved cognitive ability by the gardening intervention.Engaged 24 sessions of 60 min gardening activity sessions twice per week of activities involving garden design and planning, planting transplants, sowing seeds, cutting, garden maintenance, and hydroponics.
  • Cognitive ability

  • Brain-derived neurotrophic factor (BDNF)

  • Serum metabolites

  • Korean Mini-Mental State Examination (MMSE)

71.8 ± 4.8
50% ♀
40KoreaQuasi-experimental79%
Yang et al. (2022)
[54]
Therapeutic gardening is promising and applicable as a nature-based intervention to improve the mental health of individuals experiencing psychological distress especially in the COVID-19 pandemic.A therapeutic gardening program that involved engaging in setting up kitchen garden, setting up seasonal bed, setting up herb bed, health lecture, setting up aquatic garden, setting up rock garden, sowing, mulching, composting and irrigation, removing weed as a group for 30 sessions for 3 h twice per week for 15 weeks.
  • Depression: Mental Health Screening Tool for Depression (MHS:D)

  • Anxiety: Mental Health Screening Tool for Anxiety (MHS:A)

  • Daily activities: The Engagement in Daily Activity Scale (EDAS)

  • Quality of life: World Health Organization Quality of Life—Brief (WHOQOL-BREF)

  • Mindfulness: Korean Mindful Attention Awareness Scale (MAAS)

55.5
79% ♀
111KoreaMulti sites trial95%
Park et al. (2019)
[36]
The levels of brain nerve growth factors related to memory were significantly increased after the gardening activity in senior adults.A 20-min gardening activity intervention with low-to-moderate intensity gardening activities such as digging, raking, planting/transplanting, fertilizing, and watering.
  • BDNF levels

  • Vascular endothelial growth factor (VEGF) levels

  • Platelet-derived growth factor (PDGF) levels

76.6 ± 6.0
68% ♀
41South KoreaPre-post intervention study100%
Kotozaki (2020)
[50]
Provide evidence that the effects of gardening activities on the psychological health of postpartum women.Engagement in 8 weeks of gardening activity involving planting and nurturing plants, weeding, and gathering flowers they grew, and made an herbarium of dried flowers.
  • Rhythmicity score of the Revised Infant Temperament Questionnaire (RITQ)

  • Attachment score Mother attachment-to-Infant Bonding Scale (MIBS-J)

  • Stress regarding parents score-Parenting Stress Index (PSI)

  • Postpartum depression-Edinburgh Postpartum Depression Scale (EPDS)

30.4 ± 3.2
100% ♀
15JapanExploratory pre- and post-intervention pilot study95%
Kotozaki (2020)
[55]
Horticultural activity may improve mental health and cognitive functions in postpartum women.Engagement in 8 weeks of gardening activity involving planting and nurturing plants, weeding, and gathering flowers they grew, and made an herbarium of dried flowers.
  • The trail making test (TMT)-A and TMT-B were significantly decreased.

  • The Digit Symbol Substitution Test was significantly increased.

  • The Edinburgh Postpartum Depression Scale, State-Trait Anxiety Inventory, and anger hostility, confusion-bewilderment, fatigue-inertia, tension-anxiety, Total Mood Disturbance of the Profile of Mood States 2 was significantly decreased, respectively.

  • Vigor-activity and friendliness of the Profile of Mood States 2 were significantly increased.

30.4
100% ♀
15JapanExploratory pilot study95%
Han et al. (2018)
[40]
Horticultural therapy can improve the stress levels and physical functional abilities of elderly people with mental health problems.A horticultural therapy program that involved 10 once a week 90 min sessions of plant cultivating activities such as making plant beds, planting transplants, watering, weeding, and harvesting.
  • Cortisol levels

  • Physical functional ability

80.1 
92% ♀
28South KoreaPre- and post-test design with experimental and control groups79%
Van Den Berg & Custers (2011)
[39]
Gardening can promote relief from acute stress.
Reported on reduction of cortisol levels and mood regulation.
30 minutes of outdoor gardening or indoor reading
  • Salivary cortisol levels

  • Self-reported mood

57.6
73% ♀
30The NetherlandsExperimental design79%
Smith-Carrier et al. (2021)
[52]
Therapeutic gardening is a valuable practice for people with dementia.Therapeutic gardening that involved series of six waves that involved planning, planting, tending, pruning and harvesting for five months in groups.
  • Engagement

  • Quality of life

  • Well-being

  • Positive mental and physical well-being

Elderly6CanadaQualitative design95%
Widodo et al. (2019)
[47]
Horticultural therapy to plant flowers had a positive effect on stress levels in the elderly.Horticultural therapy was an activity of planting and caring for flower plants through planting, weeding, watering, fertilizing for 6 months.
  • Qualitative picture of brain waves or brain mapping about stress

45–59
21% ♀
14IndonesiaQuasi experimental design71%
Christie et al. (2016)
[49]
Immersion in horticultural activity may be an effective treatment modality in promoting positive health benefits to service users.A 12-month horticultural therapy intervention that involved raking, digging, planting, watering, adding mulch and potting up plants.
  • Subjective health

  • Wellbeing

  • Reduced stress

  • Life satisfaction

52.3
71% ♀
7UKQualitative design90%
Hassan et al. (2018)
[58]
Gardening activities contribute to significant lower anxiety levels after gardening tasks.Transplanting activity using soil with plants or translating without plants 15 min in duration
  • Psychophysiological

  • Relaxing effects

  • Reduction of stress

79.5
100% ♀
40ChinaExperiment design95%
Styck and George (2022)
[56]
Gardening has a positive impact on psychological wellbeing of person living with dementia.Gardening sessions that involved watering, weeding, fertilizing, and harvesting the crops twice weekly at outdoor raised beds over a 2-month duration
  • Physical benefits

  • Mood improvement

  • Sense of community

  • Reminiscence

  • Sense of self

  • Sense of purpose

  • Pride

> 50
90% ♀
10MichiganCluster randomized pilot study (Qualitative)95%
Odeh et al. (2022)
[60]
Group-based gardening or art-making can provide quantitatively measurable improvements in healthy women’s psychosocial health status.Group based indoor art making and 15 gardening activities that include planting seeds and vegetative propagation by cuttings/divisions; transplanting; and simulated harvest.
  • Anxiety

  • Depression symptoms

  • Mood disturbance

  • Stress

  • Satisfaction with discretionary social activities

  • Quality of life measures

  • Cardiac physiological data (heart rate and blood pressure)

32–33
100% ♀
42Gainesville or FloridaRandomized controlled trial96%
Makizako et al. (2019)
[38]
Exercise may improve memory, while horticultural activity may not.Exercise and horticultural activities involving 20 weekly 60- to 90-min sessions involving group crop-related activities such as cultivating, growing, and harvesting.
  • Geriatric Depression Scale-15 (Gds-15)

  • Wechsler Memory Scale-Revised

  • Walking speed

  • 2-minute walking test scores

  • Social network

  • Life space

  • Subjective daily physical activity

73.1
50% ♀
89JapanRandomized controlled trial93%
Vujcic et al. (2017)
[57]
Nature-based therapy is recommended to psychiatric patients as a form of occupational or supportive therapy.Horticulture therapy that involved exposure to green environments and plot weeding and potting collected fruits thrice a week for an hour for four weeks.
  • Depression

  • Anxiety

  • Stress

45.35
70% ♀
30SerbiaRandomized controlled trial75%
Kim et al. (2021)
[43]
Activities of transplanting have a positive effect on the cognitive function of elderly people by increasing brain activity.Horticultural and nonhorticultural activities as leisure activities
  • Relative beta index

  • Gamma index

  • Low beta index

  • Ratio of sensorimotor rhythm to theta indices

  • Total mood disorder score

74.0
50% ♀
58South KoreaCross-over experimental design95%
Hewitt et al. (2013)
[53]
A meaningful guided activity program can maintain or improve well-being in the presence of cognitive deterioration.2 hours per week structured activity programme of gardening
  • MMSE

  • Bradford Well-Being Profile

  • Large Allen Cognitive Level Screen (LACLS)

  • Pool Activity Level (PAL)

43–65
67% ♀
12UKMixed-method study95% (quantitative)
100% (qualitative)
Lai et al. (2022)
[29]
Evidence that gardening can stimulate functional connectivity in the brain, activation of positive emotions, and mindfulness in the brain.Three stages of horticultural activities of site preparation and sowing, fertilizing and weeding, and harvesting for 6 weeks
  • Physiological changes during different stages of horticultural activity

  • Functional magnetic resonance imaging (fMRI) functional connectivity of brain regions

  • Activation of positive emotions

  • Mindfulness in the brain

  • Creativity

  • Attention

  • Relaxation

  • Reduction of depression

23
47% ♀
23TaiwanPre-post experimental study95%
Lee et al. (2021)
[44]
Results showed that each horticultural activity showed promotion of brain activity. Study confirmed the possibility of horticultural activity as a short-term physical intervention to improve attention levels and emotional states.Engagement in horticultural activities that involved raking, sowing seed, hoeing, weeding, pruning, watering, over two minutes intervals and one-minute rests for 90 minutes.
  • Brain activity

  • Emotional changes

  • Attention level

  • Fatigue

  • Tension

  • Vigor

24.97 ± 2.62
50% ♀
60KoreaExperimental study95%
Masuya & Ota (2014)
[51]
Elderly people with mild to moderate dementia improved after participation in the horticultural activities program.Horticultural activities such as seeding and transplanting plants into individual pots, thinning and harvesting them for 30–40 min once a week for six consecutive weeks.
  • Vitality index (Vi)

  • Geriatric Depression Scale (Gds-15)

  • Activities of Daily Living (ADL-20) Scale

  • Quality of life

  • MMSE

88
82% ♀
9TokyoNon-controlled trial100%
Tao et al. (2022)
[59]
Choosing suitable plant types in horticultural activities is positively significant in enhancing affect.Horticultural activities that involved digging, transplanting, and watering for 30 min
  • Blood pressure

  • Positive/negative affects

  • Heart rate variability (RMSSD, SDNN, And LF/HF)

  • Controlled covariate environmental parameters (field temperature, humidity, and noise)

22.5
Gender not reported
152ChinaRandomized field-controlled trial86%
Toyoda et al. (2017)
[46]
The need for collating external information corresponding to changes in the external environment induced repeated frontal pole activation during the gardening tasks.Engagement in repeated gardening tasks involving seeding task and a watering task
  • Activation of the frontal pole

  • Oxygenated hemoglobin values in the frontal pole

67.7
63%
24JapanQuantitative design 100%
Ng et al. (2018)
[42]
Horticultural therapy can reduce plasma interleukin-6 (IL-6), thus may prevent inflammatory disorders, and through maintaining plasma CXCL12 (SDF-1α), may maintain hematopoietic support to the brain. Thus, may enhance the well-being of older adults.Engagement in 15 sessions of horticultural activities involving indoor gardening, growing, maintaining and harvesting vegetables and herbs, as well as guided walks in the various parks
  • IL-1β, IL-6, sgp-130

  • CXCL12/SDF-1α, CCL-5/RANTES

  • BDNF

  • Cortisol and DHEA (dehydroepiandrosterone)

  • Cognitive functions

  • Depression

  • Anxiety

  • Psychological well-being

  • Social connectedness and satisfaction with life

67.1
Gender not reported
59SingaporeRandomized controlled trial79%

< 50%: poor quality; 50–59%: adequate quality; 60–79%: good quality; > 80%: strong quality; ♀: female; **: QualSyst tool for quantitative and qualitative studies was used to appraise the quality. The mixed method was appraised by evaluating both checklists [32]