Presentation of changes in motor (changes in MSV3D expressed as Romberg ratio ST, motor DT ratio, Romberg ratio DT, and motor DT ratio EC) and cognitive (change in the number of arithmetic steps expressed as cognitive DT ratio) performance between the different conditions relative to their defined baseline condition (see Figure 1), expressed as a ratio (median, min–max)
Ratios | HC | pwMS | Test value* (P) |
---|---|---|---|
Changes in motor performance | |||
Romberg ratio ST | 1.38 (0.71–2.26) | 1.55 (0.63–5.91) | 1,749 (0.012) |
Motor DT ratio EO | 1.19 (0.61–5.17) | 1.43 (0.64–17.08) | 2,813 (0.444) |
Romberg ratio DT | 1.08 (0.32–2.50) | 1.09 (0.13–2.95) | 2,313 (0.809) |
Motor DT ratio EC | 1.03 (0.31–4.04) | 0.97 (0.39–6.07) | 2,107 (0.284) |
Changes in cognitive performance | |||
Cognitive DT ratio | 1.17 (0.63–2.25) | 1.10 (0.50–2.75) | 1,932 (0.075) |
* Statistical tests for group comparison: Mann-Whitney U test (Mann-Whitney U value). DT: dual task; EC: eyes closed; EO: eyes open; HC: healthy controls; MSV3D: Mean angular Sway Velocity in 3D; pwMS: persons with multiple sclerosis; ST: single-task
The supplementary materials for this article are available at: https://www.explorationpub.com/uploads/Article/file/100482_sup_1.pdf.
We express our sincere gratitude to Karen Otte for her invaluable support and expertise and her contributions in regard of data curation, formal analysis, resources and software. We further acknowledge institutional support for study conduct at Berlin site by NCRC - Neuroscience Clinical Research Center funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2049–390688087 and Charité-BIH Clinical Study Center.
PA: Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing—original draft, Writing—review & editing. FR and SCR: Investigation, Writing—review & editing. EMD and MW: Writing—original draft, Writing—review & editing. DD: Data curation, Investigation, Resources, Writing—review & editing. RA and AC: Data curation, Investigation, Writing—review & editing. JBS: Project administration, Resources, Writing—review & editing. CH: Project administration, Resources, Supervision, Writing—review & editing. FP: Funding acquisition, Project administration, Resources, Supervision, Writing—review & editing. TSH: Conceptualization, Project administration, Data curation, Formal analysis, Investigation, Resources, Supervision, Writing—original draft, Writing—review & editing.
The authors declare that they have no conflicts of interest.
All study protocols were approved by the ethics committees of the conducting institutions (CIS EA1/182/10, VALKINECT EA1/339/16, VIMS EA1/163/12 by Charité – Universitätsmedizin Berlin; AMBOS PV5408, OPRIMS PV3961, by Universitätsklinikum Hamburg-Eppendorf).
All participants at both study centers provided informed consent for data acquisition and data sharing and analysis.
Not applicable.
Raw data for this analysis are archived at the institution which acquired the data without consent for open sharing. Requests for data sharing should be addressed to the corresponding author and decisions will be made in accordance with the principal investigators of concerned studies.
Not applicable.
© The Authors 2024.