Table Info

Table 4.

The results of Spearman’s rank correlations between changes in motor and cognitive performance expressed as ratios (see Figure 1) with disease severity (EDSS), motor (maximum walking speed, MSV3D in EC condition), and cognitive (SDMT) functional levels. The correlation coefficient rho and the P-value are provided. Significant results are highlighted using asterisks: P of 0.05–0.001 (*) and P < 0.001 (**)

Ratios	Correlation coefficient (rho) and P value (P)	EDSS	SMSW	MSV3D EC	SDMT
Ratios in pwMS
Romberg ratio ST	Rho	0.003	0.056	0.526**	0.018
Romberg ratio ST	P	0.978	0.564	< 0.0001	0.848
Motor DT ratio EO	Rho	–0.114	0.021	–0.089	0.147
Motor DT ratio EO	P	0.23	0.829	0.348	0.120
Romberg ratio DT	Rho	–0.005	0.212*	0.134	0.067
Romberg ratio DT	P	0.958	0.026	0.158	0.480
Motor DT ratio EC	Rho	–0.14	0.186	–0.338**	0.237*
Motor DT ratio EC	P	0.14	0.051	< 0.0001	0.012
Cognitive DT ratio	Rho	0.139	–0.018	0.226*	–0.214*
Cognitive DT ratio	P	0.143	0.850	0.016	0.023
Ratios in HC
Romberg ratio ST	Rho		0.098	0.737**	0.068
Romberg ratio ST	P		0.537	< 0.001	0.667
Motor DT ratio EO	Rho		–0.13	–0.147	–0.055
Motor DT ratio EO	P		0.413	0.353	0.732
Romberg ratio DT	Rho		0.049	0.203	0.037
Romberg ratio DT	P		0.758	0.197	0.848
Motor DT ratio EC	Rho		–0.027	–0.496*	–0.177
Motor DT ratio EC	P		0.867	0.001	0.263
Cognitive DT ratio	Rho		0.037	0.083	–0.197
Cognitive DT ratio	P		0.818	0.600	0.211

DT: dual task; EC: eyes closed; EDSS: expanded disability status scale; EO: eyes open; HC: healthy controls; MSV3D: Mean angular Sway Velocity in 3D; pwMS: persons with multiple sclerosis; SDMT: single digits modalities test; SMSW: short distance maximum walking speed in m/s; ST: single-task

Supplementary materials

The supplementary materials for this article are available at: https://www.explorationpub.com/uploads/Article/file/100482_sup_1.pdf.

Declarations

Acknowledgments

We express our sincere gratitude to Karen Otte for her invaluable support and expertise and her contributions in regard of data curation, formal analysis, resources and software. We further acknowledge institutional support for study conduct at Berlin site by NCRC - Neuroscience Clinical Research Center funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2049–390688087 and Charité-BIH Clinical Study Center.

Author contributions

PA: Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing—original draft, Writing—review & editing. FR and SCR: Investigation, Writing—review & editing. EMD and MW: Writing—original draft, Writing—review & editing. DD: Data curation, Investigation, Resources, Writing—review & editing. RA and AC: Data curation, Investigation, Writing—review & editing. JBS: Project administration, Resources, Writing—review & editing. CH: Project administration, Resources, Supervision, Writing—review & editing. FP: Funding acquisition, Project administration, Resources, Supervision, Writing—review & editing. TSH: Conceptualization, Project administration, Data curation, Formal analysis, Investigation, Resources, Supervision, Writing—original draft, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All study protocols were approved by the ethics committees of the conducting institutions (CIS EA1/182/10, VALKINECT EA1/339/16, VIMS EA1/163/12 by Charité – Universitätsmedizin Berlin; AMBOS PV5408, OPRIMS PV3961, by Universitätsklinikum Hamburg-Eppendorf).

Consent to participate

All participants at both study centers provided informed consent for data acquisition and data sharing and analysis.

Consent to publication

Not applicable.

Availability of data and materials

Raw data for this analysis are archived at the institution which acquired the data without consent for open sharing. Requests for data sharing should be addressed to the corresponding author and decisions will be made in accordance with the principal investigators of concerned studies.

Funding

Not applicable.

Copyright

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