Table Info

Table 1.

Lysophospholipid G protein-coupled receptors (GPCR). Nomenclature of the GPCRs and genes of S1P and LPA receptors as well as the G protein cell signaling pathways activated [2, 3]

Ligand	GPCR (protein)	Gene name Mouse/human	Other names	Signaling pathways
S1P	S1P₁	S1pr1/S1PR1	edg1, lp_B1	G_i/o
	S1P₂	S1pr2/S1PR2	edg5, lp_B2, AGR16, H218	G_i/o, G_q, G_12/13
	S1P₃	S1pr3/S1PR3	edg3, lp_B3	G_i/o, G_q, G_12/13
	S1P₄	S1pr4/S1PR4	edg6, lp_C1	G_i/o, G_12/13, (G_s)
	S1P₅	S1pr5/S1PR5	edg8, lp_B4, Nrg-1	G_i/o, G_12/13, (G_s)
LPA	LPA₁	Lpar1/LPAR1	vzg1, edg2, lp_A1	G_i/o, G_q, G_12/13
	LPA₂	Lpar2/LPAR2	edg4, lp_A2	G_i/o, G_q, G_12/13
	LPA₃	Lpar3/LPAR3	edg7, lp_A3	G_i/o, G_q
	LPA₄	Lpar4/LPAR4	GPR23, p2y9	G_s, G_q, G_12/13
	LPA₅	Lpar5/LPAR5	GPR92	G_q, G_12/13
	LPA₆	Lpar6/LPAR6	p2y5	G_s, G_12/13

S1P₄ and S1P₅ primarily signal through G_i/o and G_12/13, although there is some suggestion that they can signal through G_s (parentheses) under certain circumstances

Declarations

Acknowledgments

I would like to thank Dr. Daniel Stovall, Layla Herndon and Mallika Singh for critical reading of the manuscript.

Author contributions

EB: Writing—original draft, Writing—review & editing.

Conflicts of interest

The author declares no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

E.B. was supported by the National Institute of General Medical Sciences of the National Institutes of Health [P20GM103499]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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