Multivariate regression analysis of risk factors for chronic DILI
Variable
β
SE
Wald
P value
OR value (95% CI)
T0.5ALT (day)
0.020
0.006
10.050
0.002
1.020 (1.008–1.032)
T0.5GGT (day)
0.019
0.006
9.231
0.002
1.019 (1.017–1.031)
Clinical classification
Hepatocellular
-
-
13.137
0.004
-
Cholestatic
1.875
0.565
11.107
0.001
6.520 (2.155–19.728)
Mixed
0.797
0.704
1.281
0.258
2.220 (0.558–8.829)
Abnormal liver biochemical examinations
1.069
0.425
6.335
0.012
2.911 (1.267–6.690)
T0.5ALT, T0.5GGT: time when ALT and GGT decrease from peak to below 50%, respectively; -: none
Declarations
Author contributions
QW: Data curation, Investigation, Methodology, and Writing—original draft. LL: Methodology and Writing—review & editing. XZ and JY: Data curation, Writing—original draft, and Writing—review & editing. JG: Methodology, Writing—original draft and Writing—review & editing. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
The study was approved by the ethical committee of Zhongshan Hospital affiliated to Fudan University, Shanghai, China. The study protocol conformed to the provisions of the Declaration of Helsinki.
Consent to participate
Informed consent to participate in the study was obtained from all participants.
Consent to publication
Informed consent to publication was obtained from relevant participants.
Availability of data and materials
All the citations and data included in this manuscript are available upon request by contact with the corresponding author.
Funding
This work was funded by the National Fund of Nature Science of P.R. China [91129705, 81070340] and Shanghai Pujiang Talent Program [09PJ1402600]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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