LncRNAs modulated in HLSC-EV treated mice in comparison with NASH mice. Fold regulation expression of each lncRNA with respect to NASH mice was calculated using ΔΔCt method
Symbol | Fold regulation |
---|---|
Atxn7l1os2 | –4.16 |
Jpx | –4.13 |
5830432E09Rik# | –3.48 |
D930015M05Rik# | –3.29 |
Gm16998 | –3.1 |
Gm16575 | –3.07 |
Gm16754# | –3.03 |
Neat1# | –2.68 |
Meg3# | –2.66 |
4933427G23Rik# | –2.54 |
Dlx1as | –2.54 |
Gm17354 | –2.43 |
Gm15050# | –2.42 |
Gm16892 | –2.41 |
Gm17275 | –2.38 |
Gm4211 | –2.35 |
5530601H04Rik | –2.3 |
Gm4117# | –2.29 |
1810019N24Rik# | –2.24 |
Firre | –2.2 |
A330023F24Rik | –2.18 |
Peg13 | –2.17 |
Slc2a4rg-ps | –2.16 |
A930024N18Rik# | –2.11 |
Gm17586 | –2.04 |
Gm17388 | –2.04 |
Redrum | 2.33 |
# LncRNAs modulated both in NASH mice compared with healthy mice, and in HLSC-EV treated mice compared with NASH mice
The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/100525_sup_1.pdf.
G Chiabotto: Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing—original draft. EC: Formal analysis, Investigation, Methodology, Validation, Visualization. CP: Investigation. MBHS: Investigation, Methodology, Formal Analysis. MC: Methodology. G Camussi: Funding acquisition, Resources, Writing—review & editing. SB: Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing—review & editing. All authors have read and agreed to the published version of the manuscript.
G Camussi is a component of the scientific advisory board of Unicyte and is named inventor in a related patent (WO2006126219-A1). The other authors declare that they have no conflict of interest.
HLSCs were generated from one donor liver. The permission was obtained by the National Transplant Center in accordance with Italian legislation. The animal study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Italian Health Ministry (authorization number: 419/2016-PR, 26/04/2016).
Not applicable.
Not applicable.
All datasets generated for this study are included in the manuscript and the supplementary files.
This research was funded by grant “Terapie avanzate per processi fibrotici cronici” [Progetto EVER, codice domanda 320-39], by grant RiLo-2020, and by Unicyte AG (Oberdorf, NW, Switzerland). The funders had no role in the study design, data collection, analysis and interpretation of the data, the decision to publish, or the preparation of the manuscript.
© The Author(s) 2023.