Table Info

Table 1.

Percentage of cholestastic DILI in different registries reported in the literature

Registry		Spanish DILI Registry	Latin America	DILIN Registry (USA)	India	China	Korea	Japan	Pakistan
Type of study		Prospective	Prospective	Prospective	Prospective	Retrospective	Prospective	Prospective	Retrospective
Total DILI cases		843	367^*	899	1,288	1,985	371	307	462
Pattern of damage, n (%)	Hep	482 (57)	199 (62)^*	484 (53.8)	362 (29.7)	1,422 (71.6)	283 (76.3)	197 (64)	116 (25.1)
	Chol	173 (21)	123 (38)^#	210 (23.4)	521 (42.8)	254 (12.8)	33 (8.9)	48 (16)	260 (56.2)
	Mix	188 (22)	NA	205 (22.8)	334 (27.4)	309 (15.6)	55 (14.8)	62 (20)	86 (8.7)
Main implicated agents, individually (pharmacological group)		Amoxicillin-clavulanate (Antiinfectives)	Amoxicillin-clavulate (NA)	Amoxicillin-clavulanate (Antiinfectives)	Antituberculous (Antiinfectives)	Azithromycin (Antibiotics) Gu-kang capsule (Chinese traditional patent medicine)	NA (Herbal medications)	NA (Anti-inflammatory drugs)	Antituberculous (Antiinfectives)
HILI cases, n (%)		32 (4)	29 (8)	85 (10)	179 (13.9)	563 (28)	270 (73)	27 (8.7)	42 (9)
References		[3]	[4, 5]	[6]	[7]	[8]	[9]	[10]	[11]

^* 322 patients were cases due to conventional medicines, 29 by herbs and 16 by anabolic androgenic steroids (AAS); ^# percentage of cholestatic and mixed DILI cases together. Percentage of pattern of damage only includes results of conventional medicines. Chol: cholestatic; DILIN: Drug-Induced Liver Injury Network; Hep: hepatocellular; HILI: herbal and dietary supplements-induced liver injury; Mix: mixed; NA: not available

Declarations

Author contributions

JMPB and JPTO equally contributed to: Conceptualization and Writing—original draft. RJA: Conceptualization, Writing—original draft, and Writing—review & editing. MGC: Writing—review & editing. All authors have read and agreed to the published version of the manuscript.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Grants from Instituto de Salud Carlos III (ISCIII) cofounded by Fondo Europeo de Desarrollo Regional—FEDER [FIS 21_01248, PI18/00901, UMA18-FEDERJA-193]. CIBERehd is funded by Instituto de Salud Carlos III (ISCIII). All authors are members of the COST ACTION [CA-17112] Prospective European Drug-Induced Liver Injury Network supported by COST (European Cooperation in Science and Technology), www.cost.eu. JMPB holds a Rio Hortega contract [CM21/00074] from ISCIII. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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