Table Info

Table 4.

Genetic factors related to cholestasis-induced by xenobiotics

Association	HLA type	References
General association with cholestatic/mixed DILI (High positive predictive value)	DRB115* DQB106*	[115]
	A33:01*^¥	[65]
Association with specific agents (High positive predictive value)
Terbinafine Fenofibrate Ticlopidine	A33:01*	[65, 118]
Amoxicillin-clavulanate	A0201* B11501* B1801* DQB102* DQB10602* DQR106* DRB107* DRB115* DRB50101*	[119]
Flucoxacillin	B5101* B57-03*	[12, 115]
Oral contraceptives	ABCB11 1331T>C polymorphism	[22]

^¥ Excluding cases of amoxicillin-clavulanate and flucoxacillin

Declarations

Author contributions

JMPB and JPTO equally contributed to: Conceptualization and Writing—original draft. RJA: Conceptualization, Writing—original draft, and Writing—review & editing. MGC: Writing—review & editing. All authors have read and agreed to the published version of the manuscript.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Grants from Instituto de Salud Carlos III (ISCIII) cofounded by Fondo Europeo de Desarrollo Regional—FEDER [FIS 21_01248, PI18/00901, UMA18-FEDERJA-193]. CIBERehd is funded by Instituto de Salud Carlos III (ISCIII). All authors are members of the COST ACTION [CA-17112] Prospective European Drug-Induced Liver Injury Network supported by COST (European Cooperation in Science and Technology), www.cost.eu. JMPB holds a Rio Hortega contract [CM21/00074] from ISCIII. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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