Presence of acutely decompensated cirrhosis [12]

Patient experiences hepatic and extrahepatic organ failures assessed by CLIF-SOFA score [13]

CLIF-SOFA score is used to confirm organ failure by investigating the function of the brain, kidney, liver, coagulation, circulation, and respiration [12]

Manifestations of acute hepatic decompensation include coagulopathy, hepatic encephalopathy, ascites, gastrointestinal (GI) hemorrhage, and bacterial infections [13]

High short-term mortality rate [13]

Patient with chronic liver disease or cirrhosis (identified or unidentified) [13]

Acute hepatic injury evident by jaundice and coagulopathy, the presence of ascites and/or hepatic encephalopathy within a month [13]

No extrahepatic organ failures/dysfunction considered [18]

Events considered acute insults if they cause acute liver decompensation events such as jaundice, ascites or hepatic encephalopathy, and coagulopathy [12, 18]

High 28-day mortality rate [13]

2 or more extrahepatic organ failures including grade III and IV hepatic encephalopathy, mechanical ventilation, renal replacement therapy, and shock [13]

Presence of acutely decompensated cirrhosis [12]