The scores of organ failure (OF) [1, 25]

CharacteristicsAPASL-AARCSimplified EASL-SOFA
Liver
Total bilirubin (mg/dL)		1: < 15
2: 15–25
3: > 25		1: < 6
2: 6–12
3: > 12
Kidney
Creatinine (mg/dL)		1: < 0.7
2: 0.7–1.5
3: > 1.5		1: < 2
2: 2–3.5
3: > 3.5 or RRT
Cerebral
Degree of HE (West-Haven)		1: 0
2: 1–2
3: 3–4		1: 0
2: 1–2
3: 3–4
Coagulation
INR		1: < 1.8
2: 1.8–2.5
3: > 2.5		1: < 2
2: 2–2.5
3: > 2.5
Circulation
APASL: lactate (mmol/L)
CLIF-SOFA: MAP (mmHg)		1: < 1.5
2: 1.5–2.5
3: > 2.5		1: ≥ 70
2: < 70
3: need for vasopressors
Respiration
PaO2/FiO2 or sPO2/FiO2		-1: > 300; > 357
2: 200–300; 214–357
3: ≤ 200; ≤ 214
ScoreGrade 1: 5–7
Grade 2: 8–10
Grade 3: 11–15		Age and WBC count are added and the CLIF-ACLF score is calculated:
10 × [0.33 × CLIF-C OFs + 0.04 × age + 0.63 × Ln(WBC) − 2]

ACLF: acute-on-chronic liver failure; APASL: Asian Pacific Association for the Study of the Liver; AARC: APASL-ACLF research consortium; CLIF-SOFA: Chronic Liver Failure-sepsis-related organ failure assessment; EASL: European Association for the Study of the Liver; HE: hepatic encephalopathy; INR: international normalized ratio; MAP: mean arterial pressure; PaO2: partial pressure of arterial oxygen; FiO2: fraction of inspired oxygen; sPO2: pulse oximetric saturation; RRT: renal replacement theraphy; WBC: white blood cell