Clinical trials of ICIs in advanced MSI colorectal cancer

StudiesNCTPhaseNDrugBOR (%)CR (%)DFR (%)
2-year
DFR (%)
3-year
Ref.
Lenz, 2022NCT04008030II/1L45Ipilimumab/nivolumab651373 (57–84.5)-[32]
André, 2022NCT02060188II/≥ 2L119Ipilimumab/nivolumab55363 (53–71)60 (50–68)[35]
Overman, 2018NCT02060188II/≥ 2L74Nivolumab51350 (38–61)-[34]
Overman, 2024NCT02060188II/> 2L50Relatlimab/nivolumab481651 (37–64)38 (24–52)[36]
Le, 2020NCT02460198II/2L61Pembrolizumab33331-[40]
Le, 2020NCT02460198II/> 2L63Pembrolizumab33837-[40]
Diaz, 2022NCT02563002III/1L307Pembrolizumab vs CHT45 vs 3313 vs 448.3 (39.9–56.2)42.3 (34–50.4) vs 11.1 (6.1–17.9)[42]
Andre, 2024NCT04008030III/1L505Ipilimumab/nivolumab vs nivolumab vs CHT--72 vs 14-[43]
Kim, 2020NCT03150706II/> 2L30Avelumab2414--[37]
Taïeb, 2023NCT03186326II/2L122Avelumab vs CHT30 vs 267 vs 525 vs 10-[38]
Oh, 2022NCT03435107II/> 2L30Durvalumab42---[39]

ICIs: immune checkpoint inhibitors; MSI: microsatellite unstable; ipilimumab: anti-CTLA4; nivolumab: anti-PD-1; relatimab: anti-LAG3; pembrolizumab: anti-PD-1; CHT: chemotherapy; avelumab: anti-PD-L1; durvalumab: anti-PD-L1; BOR: best overall response; CR: complete response; DFR: disease-free rate; NCT: National Clinical Trial; Ref.: reference