Studies evaluating biomarkers in patients treated with ICIs in MSI cancer, with adapted REMARK criteria

StudiesNBiomarkerProspective setControl armValidation setRecommendationRef.
Mandal, 201933MSI sensorNONONOC[47]
Georgiadis, 201923MSI sensorNONONOC[48]
Kawazu, 2022114HLA-ABCNOYESNOB[54]
Middha, 201913B2MNONONOC[55]
Germano, 202138B2MNONONOC[56]
Zhang, 202235B2MNONONOC[57]
Schrock, 201922TMBNONONOC[49]
Loupakis, 202080TMB/TILSNONONOC[50]
Chida, 202145TMBNONONOC[51]
Manca, 2023110TMBNONONOC[52]
Westcott, 202326Clonal neoantigen burdenNONONOC[53]
Quintanilha, 2023320MSI (NGS)NOYESYESB[46]
Pietrantonio, 2021305NomogramNONOYESC[60]
Sui, 202266Inflammatory signatureNONOYESC[58]
Corti, 2021163Inflammatory signatureNONONOC[59]
Saberzadeh-Ardestani, 202333Inflammatory signatureNONONOC[61]
Gallois, 2023138Stromal signatureNONOYESC[62]
Chida, 202236CMSNONONOC[63]
Sui, 202143DKK1NONONOC[64]
Bortolomeazzi, 202129WNT/TMB/B2MNONOYESC[65]
Ratovomanana, 2023129Multiplex MSI signature/TGF-β signatureNONOYESC[71]

ICIs: immune checkpoint inhibitors; MSI: microsatellite unstable; HLA: human leukocyte antigen; B2M: beta 2 microglobulin; TMB: tumor mutational burden; TILS: tumor infiltrating lymphocytes; NGS: next generation sequencing; CMS: consensus molecular subtype; DKK1: Dickkopf 1; TGF-β: transforming growth factor beta