Investigational novel therapies for HBV infection (selected)

Categories of
novel therapies
Types and compoundsClinical trial (Phase)References
Direct-acting antivirals (DAAs)Capsid assembly modulators (CAMs)
    Bersacapavir (JNJ-6379)Phase 2b[67]
    Morphothiadin (GLS4)Phase 2[68]
    EDP-514Phase 1[69]
siRNA agents
    JNJ-3989Phase 2b[67]
    RG6346Phase 2[70]
    AB7-29-001Phase 2[71]
Antisense oligonucleotides (ASOs)
    Bepirovirsen (GSK32228836)Phase 2[72]
    RO7062931Phase 1[73]
HBV entry inhibitors
    BulevirtidePhase 2[78]
HBsAg inhibitors
    REP2139Phase 2[73]
Host-directed antivirals (HDAs)Immunomodulators, innate immune response
    RO7020531Phase 1[74]
    SelgantolimodPhase 2[75]
Immunomodulators, adaptive immune response
    EpcoritamabPhase 2a[68]
Therapeutic vaccines
    BRII-179Phase 2[76]