Table Info

Table 3.

Survival of patients with MSS according to PD-L1 CPS

Known PD-L1 CPS	N, %	PFS		OS
Known PD-L1 CPS	N, %	Median, months	HR, 95% CI	Median, months	HR, 95% CI
< 1 ≥ 1	4 (5.7) 67 (94.3)	1 3	0.32 (0.10–0.96)	2 6	0.54 (0.19–1.53)
< 5 ≥ 5	43 (60.5) 28 (39.4)	2 5	0.62 (0.30–1.43)	6 15	0.53 (0.24–1.14)
< 10 ≥ 10	47 (66.1) 24 (33.8)	2 5	0.44 (0.71–1.70)	6 13	0.26 (0.25–1.45)
< 20 ≥ 20	51 (71.8) 20 (28.1)	3 3	0.88 (0.32–2.59)	6 13	0.77 (0.86–2.42)

MSS: microsatellite stable; PD-L1: programmed death-ligand 1; PFS: progression-free survival; OS: median overall survival; CPS: combined positive score; HR: hazard ratio

Declarations

Acknowledgments

Authors express their appreciation to Evdokimov V. I., Fedorinov D. S., and Tsaryova A. S. for their help in collecting data. Participating centers: N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Moscow Multidisciplinary Clinical Center “Kommunarka”, Moscow Healthcare Department; Branch “Oncology Center No. 1 of the City Clinical Hospital named after S. S. Yudin of the Moscow Department of Health”; A.S. Loginov Moscow Clinical Scientific Center, Moscow Healthcare Department; Moscow City Oncology Hospital No. 62, Moscow Healthcare Department.

Author contributions

AR: Investigation, Methodology, Writing—original draft. MF: Investigation, Methodology, Writing—review & editing, Formal analysis. DP, ML, LZ, DS, MV, IP, and NB: Writing—review & editing. AT: Conceptualization, Supervision, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The research proposal was submitted at the academic meeting and approved by the local ethics committee on 23.01.2021. The Local Committee of Scientific Research Ethics at N.N. Blokhin National Medical Research Center of Oncology was registered with the Federal Service for Supervision of Health and Social Development on 10.02.2006 (license number 01-3775/06).

Consent to participate

The Local Committee of Scientific Research Ethics at N.N. Blokhin National Medical Research Center of Oncology exempted informed consent to participate in this manuscript.

Consent to publication

Not applicable.

Availability of data and materials

Requests for accessing the datasets should be directed to [Alexey Tryakin, atryakin@gmail.com].

Funding

Not applicable.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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