Plasma membrane transporters and channels involved in hepatobiliary function
Cells
Membrane
Protein
Gene
Substrates
Hepatocytes
Basolateral
NTCP
SLC10A1
Bile acids
OATP1B1
SLCO1B1
Bile acids, organic anions
OATP1B3
SLCO1B3
Bile acids, organic anions
MRP3
ABCC3
Bile acids, organic anions
MRP4
ABCC4
Bile acids, organic anions
NBC4
SLC4A5
Na+/HCO3–symporter
NHE1
SLC9A1
Na+/H+ antiporter
SK2
KCNN2
K+ channel
BSC
SLC12A2
Na+/Cl– symporter
AQP9
AQP9
Water channel
Hepatocytes
Canalicular
BSEP
ABCB11
Bile acids
MRP2
ABCC2
Organic anions
MDR1
ABCB1
Several
BCRP
ABCG2
Bile acids, steroids
MDR3
ABCB4
Phosphatidyl choline
FIC1
ATP8B1
Phosphatidyl serine
ABCG5/G8
ABCG5/G8
Cholesterol
NHE3
SLC9A3
Na+/H+ antiporter
AQP8
AQP8
Water channel
Cholangiocytes
Basolateral
OSTα/β
SLC51A/B
Bile acids, organic anions
NHE1
SLC9A1
Na+/H+ antiporter
NDCBE
SLC4A8
Cl–/HCO3– antiporter
SK2
KCNN2
K+ channel
BSC
SLC12A2
Na+/Cl– symporter
MRP3
ABCC3
Bile acids, organic anions
MRP4
ABCC4
Bile acids, organic anions
AQP4
AQP4
Water channel
Cholangiocytes
Apical
ASBT
SLC10A2
Bile acids
AE2
SLC4A2
Cl–/HCO3– antiporter
CFTR
ABCC7
Cl– channel
NBC4
SLC4A5
Na+/HCO3– symporter
AQP1
AQP1
Water channel
BCRP: breast cancer resistance protein; HCO3–: bicarbonate; KCNN2: potassium calcium-activated channel subfamily N member 2
Declarations
Author contributions
MA: writing – review & editing; SOR and AMC: writing – original draft; JJGM: supervision.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This study was funded by the CIBERehd (EHD15PI05/2016) and “Fondo de Investi-gaciones Sanitarias, Instituto de Salud Carlos III”, Spain (PI16/00598 and PI19/00819, co-funded by European Regional Development Fund/European Social Fund, “Investing in your future”); Spanish Ministry of Economy, Industry and Competitiveness (SAF2016-75197-R); “Junta de Cas-tilla y Leon” (SA063P17); AECC Scientific Foundation (2017/2020), Spain; “Proyectos de Investigación Modalidad C2”, University of Salamanca (18.K137/463AC01 and 18.K140/463AC01); “Centro Internacional sobre el Envejecimiento” (OLD-HEPAMARKER, 0348_CIE_6_E), Spain and Fundación University of Salamanca, Spain (PC-TCUE18-20_051); Fundació Marato TV3 (Ref. 201916-31). SOR was supported by a postdoctoral contract (FPU) funded by the “Junta de Castilla y Leon” (SA074P20). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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