Relationships of biomarkers to disease activity and effects of VitD/VitD supplementation on disease progression in depression and MS

CriteriaDepressionMS
sNfL (follow-up monitoring of the activity by the drop in serum levels)[4550, 54][6164]
sGFAP (lowering in serum values ​​as an indication of improvement in neuronal, axonal, and glial damage)[65, 68][66, 6971]
HPA-axis/serum cortisol levels[28, 74][31, 32, 73]
VitD deficiency[18, 71, 8284, 9196, 164, 165][97101, 138, 140143]
Antiinflammatory/proinflammatory cytokines[4, 84, 86, 88, 89][110, 149]
Sealing the BBB[113118][109112]
MG[20, 123, 128, 129][98, 121, 127]
Disorders of the gut microbiome, HPA-axis, and microbiome gut-brain-axis[2123, 150, 151, 153][103, 144, 149]
Pregnancy/postpartum phase[166174][169]