Major findings of the preclinical evidences of Cuban policosanol on stroke

AuthorYearAnimal modelDosing modeMajor findings
Arruzazabala et al. [33]1993Permanent ligature of a carotid in Mongolian gerbils Preventive single oral doses (25 mg/kg, 50 mg/kg, and 200 mg/kg)Cuban policosanol reduced clinical symptoms and mortality, associated to a TxA2 reduction and PgI2 increase
Preventive single oral doses of policosanol (25 mg/kg) plus aspirin (30 mg/kg)This combination was more effective than the respective monotherapies on clinical symptoms and mortality, showing a synergism between them
Molina et al. [35]1999Permanent ligature of a carotid in Mongolian gerbilsTherapeutic single oral doses (100 mg/kg and 200 mg/kg)Cuban policosanol (200 mg/kg) reduced clinical symptoms and mortality; and also it protected against brain histological damage
Bilateral ischemia and reperfusion in Mongolian gerbilsTherapeutic single oral doses (200 mg/kg) Cuban policosanol reduced edema and restored AMPc levels in cerebral tissue
Molina et al. [40]2013Bilateral ischemia and reperfusion in Mongolian gerbilsPreventive single oral doses of Cuban policosanol and GSE (100 mg/kg and 200 mg/kg)Both treatments inhibited similarly the hyper-locomotion, brain histological damage and plasma oxidative markers
Molina et al. [43]2015Bilateral ischemia and reperfusion in Mongolian gerbilsPreventive oral doses of Cuban policosanol (100 mg/kg and 200 mg/kg) and omega-3 fish oil (1.25 g/kg and 2.5 g/kg) during 4 weeksBoth treatments prevented global cerebral ischemia with similar efficacy on hyper-locomotion and plasma oxidative markers, but being policosanol more effective on histological damage score
Molina et al. [44]2017Bilateral ischemia and reperfusion in Mongolian gerbilsTherapeutic oral doses of Cuban policosanol (100 mg/kg and 200 mg/kg) and omega-3 fish oil (1.25 g/kg and 2.5 g/kg) during 7 daysBoth treatments reduced global cerebral ischemia with similar efficacy on neurological symptoms score and plasma oxidative markers, but being policosanol more effective on brain histological damage score
Molina et al. [45]2013Bilateral ischemia and reperfusion in Mongolian gerbilsTherapeutic single oral doses of Cuban policosanol (100 mg/kg and 200 mg/kg) and atorvastatin (10 mg/kg and 20 mg/kg)Both treatments reduced global cerebral ischemia with similar efficacy on neurological symptoms score, hyper-locomotion and brain histological damage score. Cuban policosanol produced antioxidant effects, unlike atorvastatin that did not modify it
Molina et al. [46]2018Bilateral ischemia and reperfusion in Mongolian gerbilsSingle therapeutic doses of Cuban policosanol (100 mg/kg) plus aspirin (60 mg/kg), Cuban policosanol (100 mg/kg) plus atorvastatin (20 mg/kg) and aspirin (60 mg/kg)Both combinations reduced similarly clinical symptoms, hyper-locomotion and histological damage, but with a major efficacy respect to aspirin monotherapy