Table Info

Table 1.

Effects of pesticides on health and epigenetics

Pesticide			Risks to human health		Epigenetics
Type	Reagents	Action	Diseases and health hazards	References	Epigenetic actions	Animal type	References
Organochlorine	Carbon tetrachloride Chlordane DDT DDE (metabolite of DDT) Dieldrin Heptachlor Hexachlorocyclohexanemethoxychlor Vinclozoin	Insecticide	Growth Premature birth Abortion Prostate cancer Leukemia PD Thyroid disorders Amyotrophic lateral sclerosis	[28–38]	DNA methylation (methoxychlor, vinclozoin, DDT, and DDE) Histone modification (dieldrin)	In vitro (mesencephalic, dopaminergic neuronal, and cells) Rat Mouse embryo Human	[39–45]
Organophosphorus	Acephate Chlorpyrifos Coumaphos Diazinon Dichlorvos Fonofos Parathion Methyl parathion Malathion Phosmet Triazophos	Insecticide	Brain and neurological developmental abnormalities in infants Deintellectualization Increased incidence of attention deficit hyperactivity disorder Lung cancer Lymphoma Leukemia Asthma PD Alzheimer’s disease	[46–55]	microRNA expression (dichlorvos and triazophos)	In vitro (porcine kidney and epithelial cells) Zebrafish	[56, 57]
Organophosphorus		Weeding	Carcinogenesis Reproductive dysfunction Endocrine disruption Allergic rhinitis	[58–61]	DNA methylation Histone modification microRNA expression	Japanese medaka (oryzias latipes) In vitro (PBMC and mammalian stem cell) Rats Mouse	[62–67]
Carbamate	Glyphosate Aldicarb Carbaryl Methiocarb Pirimicarb Mancozeb Maneb Thiocarbamate Propoxur	Weeding	Neurotoxicity Thyroid disease Developmental abnormalities	[68–70]	Histone modifications (propoxur)	In vitro (gastric cells)	[71]
Pyrethroids	Cyhalothrin Cypermethrin Deltamethrin Permethrin	Insecticide	Endocrine disruption	[72, 73]	DNA methylation	Human (blood)	[74]
Neonicotinoids	Clothianidin Imidacloprid Thiamethoxam	Insecticide	Abnormal neurodevelopment	[75]	Histone modifications	Mouse	[76]
Bipyridinium	Paraquat	Weeding	Neurotoxicity PD	[77]	Histone modifications	In vitro [immortalized rat, mesencephalic dopaminergic cells (N27 cells)]	[45, 78]

DDE: dichlorodiphenyldichloroethylene; PBMC: peripheral blood mononuclear cells; PD: Parkinson’s disease

Declarations

Acknowledgments

Thanks are due to Editage (www.editage.com) for English language editing.

Author contributions

TK: Writing—original draft. MY and YN: writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This article was supported in part by a Grant-in-Aid for Scientific Research [22K11781] from the Japan Society for the Promotion of Science. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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