Exploration of Neuroscience

From: Brain metastasis from the perspective of molecular mechanisms and treatment, presenting a new approach for targeting ion channels by nano drugs

Table 2. Treatment by targeting molecular mechanisms

Medicine	Cancer	Molecular mechanism target
Pembrolizumab	CNS metastases from NSCLC	PD-1
Lapatinib	HER2+ breast cancer	TKI activity associated with EGFR and HER2
Combination of lapatinib and capecitabine	Brain metastases	TKI activity associated with EGFR and HER2, inhibiting the synthesis of thymidine monophosphate
Afatinib, crizotinib, gefitinib, and erlotinib	Lung cancer and brain metastasis	ALK inhibitors
Osimertinib and ceritinib	Lung cancer and brain metastasis	Tyrosine kinase
Dabrafenib and vemurafenib	Metastatic melanoma	BRAF inhibitors

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Author contributions

ZKD: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. The author read and approved the submitted version.

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The author declares that there are no conflicts of interest.

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