Table Info

Table 2.

Clinical studies supporting the neuroprotective applications of triterpenoids

SN	Triterpenoid under study	Year	Condition	Type	Subjects	Duration	Findings	Ref
1	Ginsenoside Rd	2009	Acute ischemic stroke	Randomized, double-blind, placebo-controlled, phase 2, multicenter trial	199	14 days	Improvement in NIHSS score	[94] Clinical trial ID NCT00591084
2	Ginsenoside Rd	2012	Acute ischemic stroke	Randomized, double-blind, placebo-controlled, phase 3, multicenter trial	390	14 days	Improvement in primary outcome of acute ischaemic stroke Acceptable adverse-event profile	[93] Clinical trial ID NCT00815763
3	Centella asiatica selected triterpenes (CAST)	2022	Diabetic neuropathy	Randomized, double-blind, placebo-controlled, phase 2, trial	43	52 weeks	Reduced severity of symptoms	[96] Clinical trial ID NCT00608439
4	Licorice whole extract	2016	Acute ischemic stroke	Randomized, double-blind, placebo-controlled, phase 2, trial	75	7 days	Improvement in NIHSS score	[95] Clinical trial ID NCT02473458
5	Bacopa monnieri extract	2017	Healthy	Randomized, double-blind, placebo-controlled, phase 1, trial	75	16 weeks	NA	Clinical trial ID NCT02931747
6	Bacopa monnieri extract	2007	Schizophrenia	Randomized, open label, phase 2, trial	200	4 weeks	NA	Clinical trial ID NCT00483964

SN: serial number; NIHSS: National Institute of Health stroke scale; NA: not available

Declarations

Acknowledgments

Ms. Apoorva A. Bankar would like to acknowledge University Grants Commission (UGC), New Delhi for providing fellowship for doctoral studies.

Author contributions

AAB: Investigation, Writing—original draft, Writing—review & editing. VPN: Conceptualization, Writing—review & editing. NRK: Conceptualization, Supervision, Validation. NNI: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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