Summary of preclinical studies that describe S1R KO or antagonists in different NP models

Pain typePain modelSpecieSexLigandRouteEffect on painReferences
Central neuropathic painSpinal cord contusionMouseFE-52862i.p. 7 days↓ mechanical allodynia and thermal hyperalgesia[98]
MouseFE-52862i.p.↓ mechanical allodynia and thermal hyperalgesia[100]
MouseFKO No mechanical allodynia and thermal hyperalgesia[100]
Peripheral neuropathic painStreptozotocin-inducedRatME-52862i.p., acute, b.i.d. 7 days↓ mechanical hyperalgesia[97]
RatMPW507i.p., acute, b.i.d. 14 days↓ mechanical allodynia and thermal hyperalgesia[111]
MouseMBD-1047i.t. 7 days↓ mechanical allodynia and thermal hyperalgesia[112]
Nicotinamide-streptozotocin inducedMouseMHaloperidols.c.↓ mechanical allodynia and hyperalgesia[113]
MouseMLMH-2s.c.↓ mechanical allodynia and hyperalgesia[113]
Zucker diabetic fattyRatME-52862i.p., acute, b.i.d. 14 days↓ mechanical allodynia and thermal hyperalgesia[114]
High-fat dietMouseMKO No mechanical allodynia and thermal hyperalgesia[115]
MouseMBD-1047i.t.↓ mechanical allodynia and thermal hyperalgesia[115]
Oxaliplatin-inducedRatME-52862i.p., acute, b.i.d. 7 days↓ cold allodynia[97]
Cisplatin-inducedMouseMCM304i.p.↓ mechanical allodynia[116]
Paclitaxel-inducedMouseFE-52862s.c.↓ mechanical allodynia and cold hyperalgesia[101]
MouseFBD-1047s.c.↓ mechanical allodynia and cold hyperalgesia[101]
MouseFKO No mechanical allodynia and cold hyperalgesia[101]
RatMPW507i.p.↓ cold hyperalgesia[103]
Partial sciatic nerve ligationMouseME-52862i.p., acute, b.i.d. 21 days↓ mechanical allodynia and thermal hyperalgesia[104]
MouseME-52862i.v.10 days↓ mechanical allodynia and thermal hyperalgesia[105]
MouseMKO No mechanical allodynia and thermal hyperalgesia[102]
Chronic constriction injuryRatMBD-1047i.t.↓ mechanical allodynia[106]
RatMBD-1047p.o.↓ mechanical allodynia and cold hyperalgesia[107]
MouseMBD-1047i.t.↓ mechanical allodynia[108]
RatME-52862i.p., acute, b.i.d. 7 days↓ mechanical allodynia[97]
MouseMCM304i.p.↓ mechanical allodynia[116]

i.p.: intraperitoneal; i.pl.: intraplantar; i.t.: intrathecal; i.v.: intravenous; p.o.: oral; s.c.: subcutaneous; b.i.d.: twice daily; KO: knockout