Table Info

Table 3.

Overview of several genes related to TGFβ/BMP signaling pathway associated with diseases marked by bone overgrowth

Gene	Chr	Protein function in the TGFβ/BMP pathway	Disease (manifestation)	References
TGFβ1	19	Encodes a ligand involved in the activation of the TGFβ pathway	CED (OMIM#131300)	[180]
ALK2/ACVR1	2	Encodes the type I BMP receptor	FOP (OMIM#135100)	[177]
LEMD3	12	Encodes a nuclear membrane protein that can inhibit the TGFβ pathway	Osteopoikilosis; Buschke-Ollendorff syndrome (OMIM#166700)	[190]

Declarations

Author contributions

BP: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. ARC and LP: Writing—review & editing. JBA: Validation, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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