Table Info

Table 2.

Genotypes for statistically associated HFE alleles C282Y and H63D (%)

Population	*CCHH*	*CCHD*	*CCDD*	*CYHH*	*CYHD*	N
Controls	189 (67)	74 (26)	6 (2)	5 (2)	7 (3)	281
Cases	135 (47)	93 (33)	24 (8)	18 (6)	11 (4)	281
N	324	167	30	23	18	562

The data is represented as “n (%)” or “n”. Chi-square (χ²) test for distribution with Bonferroni adjustment P < 0.001. CCHH: non mutated; CCHD: heterozygote mutation for H63D; CCDD: homorozygote mutation for H63D; CYHH: heterozygote for C282Y; CYHD: combined heterozygote mutation for C282Y and for H63D

Declarations

Author contributions

JASdB and FPR contributed eaqually to: Conceptualization, Data curation, Writing—review & editing. Nuria PH, Nerea PH, CVP, and MdCMC: Conceptualization, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The study was included within a prospective inception gout cohort study approved by Cruces University Hospital Ethics and Clinical Investigation Committee (CEIC Cruces CEIC07/15), and it complies with the Declaration of Helsinki.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

Data can be obtained on request by contacting Fernando Perez-Ruiz (fernando.perezruiz@osakidetza.eus).

Funding

FPR was funded by a grant from Asociación de Reumatólogos de Cruces [01/2008]. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

Copyright

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