Maximum dose 800 mg daily including in those with moderate to severe CKD (stage ≥ 3)
Maximum dose should be adjusted to creatinine clearance. Because the dose recommendations in renal disease may slightly differ across countries, the task force recommends following the local summary of product characteristics.
0
100 mg every three days
5–15
50 mg twice weekly
10
100 mg every two days
16–30
50 mg every two days
20
100 mg daily
31–45
50 mg daily
40
150 mg daily
46–60
50/100 mg alternate days
60
200 mg daily
> 60
100 mg daily
80
250 mg daily
-
-
100
300 mg daily
-
-
120
350 mg daily
-
-
140
400 mg daily
eGFR: estimated glomerular filtration rate; ACR: American College of Rheumatology; EULAR: European Alliance of Associations for Rheumatology; CrCL: creatinine clearance; CKD: chronic kidney disease. -: no data
Declarations
Author contributions
HF: Conceptualization, Writing—original draft, Writing—review & editing. LKS: Conceptualization, Writing—original draft, Writing—review & editing. AG: Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.
Conflicts of interest
Angelo Gaffo, who is the Editorial Board Member of Exploration of Musculoskeletal Diseases, had no involvement in the journal review process of this manuscript. LKS reports funding from the Health Research Council of New Zealand and royalties from Up-to-Date outside this work. The other author declares that there are no conflicts of interest.
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