Table Info

Table 4.

Quality of life outcomes

Outcome	Baseline			1 year			2 year
Outcome	2-monthly urate (n = 38)	Annual urate (n = 21)	p value	2-monthly urate (n = 37)	Annual urate (n = 18)	p value	2-monthly urate (n = 36)	Annual urate (n = 14)	p value
Mobility	1.34 (0.75)	1.29 (0.64)	0.77	1.24 (0.55)	1.39 (0.7)	0.40	1.22 (0.54)	1.29 (0.61)	0.72
Self-care	1.21 (0.62)	1.10 (0.44)	0.46	1.14 (0.42)	1.22 (0.55)	0.52	1.17 (0.45)	1.07 (0.27)	0.46
Activities	1.21 (0.62)	1.38 (0.67)	0.33	1.16 (0.44)	1.33 (0.59)	0.23	1.22 (0.54)	1.36 (0.63)	0.45
Pain	1.39 (0.82)	1.52 (0.68)	0.54	1.32 (0.71)	1.61 (0.78)	0.18	1.39 (0.64)	1.36 (0.5)	0.87
Anxiety	1.18 (0.51)	1.62 (0.92)	0.02	1.14 (0.48)	1.50 (0.71)	0.03	1.19 (0.52)	1.71 (1.44)	0.06
Health score	84.32 (16.06)	77.81 (10.03)	0.10	86.43 (12.83)	79.56 (15.31)	0.09	86.64 (11.96)	82.29 (16.08)	0.30

Quality of life scores were collected prospectively using the EQ-5D-5L questionnaire incorporated into the GoutSMART app. For functional domains score of 1 indicates no difficulty, 2 slight difficulty, 3 moderate difficulty, 4 severe difficulty, and 5 extreme difficulty. The global health score is rated out of a best possible 100. Participants were invited to complete the questionnaire at monthly intervals as well as opportunistically during any reported flares. Results are given as mean (SD) with significance estimated using 2-sided student T test

Supplementary materials

The supplementary table for this article is available at: https://www.explorationpub.com/uploads/Article/file/100775_sup_1.pdf.

Declarations

Acknowledgments

Study results were presented as an oral communication at the 15th European Crystal Network workshop in 2024.

Author contributions

PLR: Investigation (principal investigator of the study), Supervision, Validation, Writing—original draft. DA: Methodology, Investigation (development of study documents and review of participants). CB: Investigation (obtained community prescribing data), Formal analysis, Validation. HA: Investigation (reviewed the hospital records for all participants). RH: Formal analysis, Writing—review & editing. AK: Software (developed the GoutSMART app and webportal), Data curation (provided IT support throughout the study). The corresponding author affirms that the manuscript is an accurate and transparent account of the study. All authors have had direct access to all study data and PLR has verified the findings presented. All authors have contributed to and approved the final manuscript.

Conflicts of interest

None of the authors have any conflicts of interest to declare.

Ethical approval

Ethical approval was obtained from South East Scotland Research Ethics Committee (Reference 18/SS/0031) and NHS Lothian Caldicott Guardian. The extension trial protocol has been uploaded with the results of the feasibility trial on ClinicalTrials.gov, NCT03274063.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

Data will be shared on reasonable request to the corresponding author. Study protocol is submitted as a supplementary file.

Funding

Support for development of the GoutSMART app and feasibility trial was provided by the NHS Lothian Charity. Conduct of the extension trial was supported by the Doris Hillier (2020) grant from the BMA Foundation for Medical Research including salary support for DA and AK. The funders had no role in the design, conduct, analysis or presentation of the study. The study was sponsored by the University of Edinburgh which reviewed all study documents but took no part in the collection, analysis, or interpretation of the data.

Copyright

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