Table Info

Table 1.

Biosimilars indicated for RA available in the United States and Canada [18, 25]

Biologic original (reference)	Biosimilar(s) available in the US	Biosimilar(s) available in Canada
TNFα-i
Adalimumab (Humira^®)	Abrilada (adalimumab-afzb) Amjevita (adalimumab-atto) Cyltezo (adalimumab-adbm) Hadlima (adalimumab-bwwd) Hulio (adalimumab-fkjp) Hyrimoz (adalimumab-adaz) Idacio (adalimumab-aacf) Simlandi (adalimumab-ryvk) Yuflyma (adalimumab-aaty) Yusimry (adalimumab-aqvh)	Abrilada (adalimumab) Amjevita (adalimumab) Hadlima (adalimumab) Hyrimoz (adalimumab) Hulio (adalimumab) Idacio (adalimumab) Simlandi (adalimumab) Yuflyma (adalimumab) Yusimry (adalimumab)
Certolizumab pegol (Cimzia^®)	None	None
Golimumab (Simponi^®)	None	None
Etanercept (Enbrel^®)	2 approved but not available	Brenzys (etanercept) Elrezi (etanercept) Rymti (etanercept)
Infliximab (Remicade^®)	Avsola (infliximab-axxq) Inflectra (infliximab-dyyb) Infliximab (infliximab) Renflexis (infliximab-abda) Zymfentra (infliximab-dyyb)	Avsola (infliximab) Inflectra (infliximab) Remsima (infliximab) Renflexis (infliximab)
CD20 antigen substrate that leads to B-cell lysis
Rituximab (Rituxin^®)	Riabni (rituximab-arrx) Ruxience (rituximab-pvvr) Truxima (rituximab-abbs)	Riabni (rituximab) Riximyo (rituximab) Ruxience (rituximab) Truxima (rituximab)
IL-6-receptor inhibitor
Tocilizumab (Actemra^®)	Tofidence (tocilizumab-bavi) Tyenne (tocilizumab-aazg)	Tyenne (tocilizumab)
Sarilumab (Kevzara^®)	None	None
Co-stimulatory inhibitor of T cell activation
Abatacept (Orencia^®)	None	None

RA: rheumatoid arthritis; TNFα-i: tumor necrosis factor α inhibitor; IL-6: interleukin-6

Declarations

Author contributions

LAS: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. JSA: Investigation, Writing—original draft.

Conflicts of interest

Both authors declare no conflicts of interest.

Ethical approval

Not applicable.

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