Table Info

Table 4.

Binding sites of neutralizing antibody or recombinant ACE2 in S protein

S protein-targeted agents	Name	Binding sites in S protein	References
Neutralizing antibody	B38	RBD: R403, D405-E406, Q409, T415-K417, D420-Y421, Y452, L454-N460, Y473-S477, F486-N487, Y489-F490, Q493-G496, Q498, T500-V503, Y505	[231]
	H4	RBD	[231]
	BD-368-2	RBD	[232]
	BD-23	RBD: G446, Y449, L452, T470, E484-F486, Y489-F490, L492-S494, G496, Q498, T500-N501, Y505	[232]
	CV30	RBD: R403, T415-K417, D420-Y421, Y453, L455-N460, Y473-S477, F486-N487, Y489, Q493, T500, G502, Y505	[233]
	EY6A	RBD: Y369, F374-S375, F377-K386, N388, L390, P412-G413, D427-F429, L517	[234]
	VHH-72	RBD: Y356-T359, F361-C366, A371-T372, G391-D392, R395, N424, I489, Y494	[235]
	S309	RBD: T333-L335, P337, G339-V341, N343-T345, K356-C361	[236]
	4A8	NTD: R246, K150, K147, H146, W153, Y145, N149	[237]
	COV57	NTD	[238]
	2-17	NTD	[238]
	5-24	NTD	[238]
	LY-CoV016	RBD: R403, D405-E406, R408-Q409, T415-K417, D420-Y421, L455-N460, Y473-S477, F486-N487, Y489, Q493, Y495, N501-G502, G504-Y505	[230]
	LY-CoV555	RBD: TYR32, ARG50, LEU55, TYR92, ARG96, TYR101, GLU102, ARG104, LEU452, GLU484, PHE486, PHE490, GLN493, SER494	[239]
	REGN10933	RBD: R403, K417, Y421, Y453, L455-F456, A475-G476, E484-Y489, Q493	[240]
	REGN10987	RBD: R346, N439-L441, K443-N450, Q498, T500	[240]
	BRII-196	RBD	[230]
	BRII-198	RBD	[230]
Recombinant ACE2	APN01	RBD	[243]
Recombinant ACE2	SBP1	RBD	[245]

ACE2: angiotensin-converting enzyme 2; RBD: receptor-binding domain; NTD: N-terminal domain

Declarations

Author contributions

FX: Conceptualization, Writing—original draft, Visualization, Writing—review & editing, Funding acquisition. YX: Writing—original draft, Visualization, Writing—review & editing. YL: Writing—original draft, Visualization.

Conflicts of interest

The authors declare no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was supported by Guangzhou Science and Technology Program Synergistic Innovation Major Project [No.: 201604020146] to FX. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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